Rheumatoid arthritis (RA) is a multifactorial disease. A combination of genetic and environmental risk factors contributes to its etiology. Several genes have been reported to be associated with susceptibility to the development of RA. The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and Japanese populations, respectively. In two recent reports, we show an association between FCRL3 and juvenile rheumatoid arthritis (JRA), and MHC2TA and acute coronary syndrome (ACS) in Mexican population. We assessed the association between three single nucleotide polymorphisms (SNPs) of the MHC2TA (-168G/A; rs3087456, and +16G/C; rs4774) and FCRL3 (-169T/C; rs7528684) genes and rheumatoid arthritis in Mexican population through a genotyping method using allelic discrimination assays with TaqMan probes. Our case-control study included 249 patients with RA and 314 controls. We found no evidence of an association between the MHC2TA -168G/A and +1614G/C or FCRL3 -169T/C polymorphisms and RA in this Mexican population. In this cohort of Mexican patients with RA, we observed no association between the MHC2TA or FCRL3 genes and this autoimmune disease.
Keywords: dermatomyositis • idiopathic inflammatory myopathy • mexican mestizoObjective: To investigate the possible association between HLA and Dermatomyositis (DM) in the Mexican mestizo population.Methods: HLA class I (A and B) and class II (DRB1* and DQB1*) were determined in 36 Mexican mestizo patients with DM and 72 healthy controls.
ResumenIntroducción: la esclerosis sistémica presenta complicaciones esofágicas hasta en el 96 % de los casos. El diagnóstico de los trastornos motores se basa en la manometría. Objetivo: describir los síntomas del tracto gastrointestinal superior y evaluar la motilidad esofágica en pacientes con esclerosis sistémica. Materiales y métodos: se realizó una serie de casos que incluyó a 24 pacientes con esclerosis sistémica. Las manifestaciones clínicas se obtuvieron de los expedientes clínicos y se realizó manometría esofágica. Resultados: los 24 pacientes fueron de sexo femenino (100 %), con edad promedio 53.5 años y evolución de la enfermedad de 5.8 años. También los 24 pacientes (100 %) presentaron síntomas gastrointestinales superiores. En la manometría el promedio de la presión basal del esfínter esofágico superior fue de 32.59 mmHg. (DS ±6.78) con presión residual de 0.95 mmHg. (DS ±16.29) y amplitud de ondas del cuerpo esofágico de 14.01 mmHg. (DS ±7.06). La presión basal del esfínter esofágico inferior fue de 8.85 mmHg. (DS ±10.71) con presión residual del de 1.28 mmHg. (DS ±16.06), con porcentaje del índice de relajación del 15.79% y con ondas no transmitidas del 91.2 %. Discusión: los síntomas descritos del tracto gastrointestinal superior y los trastornos motores esofágicos son similares a los reportados en la literatura; en el presente estudio fue común la hipotensión del esfínter esofágico inferior y la aperistalsis esofágica, favoreciendo el desarrollo de complicaciones. La manometría es esencial para el diagnóstico temprano de la dismotilidad esofágica en la esclerosis sistémica así como para la prevención de sus complicaciones. Actualmente no hay estándares de guías clínicas que recomienden la vigilancia especializada por manometría.PALABRAS CLAVE: esclerodermia sistémica, manometría, trastornos de la motilidad esofágica, gastroenterología. Abstract Introduction: systemic scleroderma implies esophageal complications in 96 % of the cases. Diagnosis of motor disorders is carried out through Manometry. Objective: to describe the symptoms of upper GI tract and to evaluate esophageal motility in patients with systemic scleroderma. Materials and methods: a series of cases were analyzed, which included 24 patients with systemic scleroderma. Clinical manifestations were collected from the medical records and esophageal manometry was performed. Results: the 24 patients were female (100 %), average age of 53.5 and evolution of disease of 5.8 years. Also, the 24 patients (100 %) presented upper GI symptoms. Manometry showed that superior basal esophageal sphincter pressure was of 32.59 mmHg. (DS ±6.78) on average with residual pressure of 0.95 mmHg. (DS ±16.29) and wave amplitude of the esophageal body of 14.01 mmHg. (DS ±7.06). Inferior basal esophageal sphincter pressure was of 8.885 mmhg (DS ±10.71), with residual pressure of 1.28 mmhg (DS ±16.06), with relaxing index average of 15.79% and with nontransmitted waves of 91,2 %. Discussion: the symptoms of the upper GI tract and the motor esophageal disorders ...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.