Several species of the Myrcia genus have been used in folk medicine to treat diabetes. Therefore, the aim of this work was to investigate the inhibitory activity of α-glucosidase and pancreatic lipase in the crude extract (EBF) and in the ethyl acetate fraction (FFA) of Myrcia hatschbachii, as well as to identify isolated phenolic compounds and to evaluate the antioxidant property and preliminary in vitro toxicity against Artemia salina. EBF (IC50: 3.21 μg/mL) and FFA (IC50: 1.14 μg/mL) showed inhibitory activity superior to acarbose (IC50: 193.65 μg/mL). In addition, they showed inhibitory effects of pancreatic lipase (IC50: 556.58 μg/mL for EBF and 532.68 μg/mL for FFA), antioxidant potential, absence of preliminary toxicity and presence of gallic andellagic acids in FFA. The relevant results in the inhibition of α-glucosidase and pancreatic lipase motivate new studies for the development of herbal medicines that assist in the treatment of diabetic patients.

RESUMO:Os lipídeos são os componentes mais abundantes do organismo e da dieta humana. Quando consumidos nas proporções recomendadas são bem tolerados, mas o excesso resulta em efeitos prejudiciais no estado de saúde ocasionando acúmulo excessivo de gordura, ganho de peso, obesidade e dislipidemia. Uma alternativa terapêutica valiosa para auxiliar no controle dos distúrbios do metabolismo lipídico em seres humanos é a inibição da lipase pancreática. A lipase é uma enzima lipolítica chave no mecanismo de digestão e absorção de lipídeos no organismo, sendo essencial para a formação dos quilomícrons, metabolismo e armazenamento de ácidos graxos e formação das lipoproteínas HDL, IDL, LDL e VLDL. Neste contexto o presente trabalho teve como objetivo fazer uma abordagem sobre os lipídeos, sua digestão e absorção e o auxílio no controle do seu metabolismo através da inibição da lipase pancreática. Palavras-chave: Lipídeos; Metabolismo Lipídico; Lipase Pancreática ABSTRACT Lipids are the most abundant components of the body and the human diet. When consumed in the recommended proportions are well tolerated, but excess results in harmful effects on health resulting in excessive accumulation of fat, weight gain, obesity and dyslipidemia. A valuable alternative therapy to assist in the control of lipid metabolism disorders in humans is the inhibition of pancreatic lipase. The lipase is a key enzyme in lipolytic digestion mechanism and the absorption of lipids in the body and is essential for the formation of chylomicrons, metabolism and storage of fatty acids and formation of HDL, IDL, LDL and VLDL lipoproteins. In this context, this study aimed to make an approach on lipids, your digestion and absorption and measure in controlling your metabolism by inhibiting pancreatic lipase.