The study was carried out to investigate the effect of grazing management (day and night) , watering regime (every other day and every three days), time of the day and season on respiration rate (RR) and rectal temperature (RT) of Sudan Desert sheep ewes (Ovis aries), During the day and three consecutive seasons, summer, autumn and winter for one year at Faragalla village, Sheikan Locality in North Kordofan State, Sudan. Meteorological data during the experimental periods were recorded. Sixty ewes were randomly assigned to the following treatments: A = Night grazing + every other day watering regime, B= Night grazing + every three days watering regime, C = Day grazing + every other day watering regime, D = Day grazing + every three days watering regime. The trial was laid out in a completely randomized design in a 2x2 factorial arrangement of treatments. Grazing management had no effect (p > 0.05) on RR of ewes, with ewes on day grazing recording slightly higher RR. However, the same factor influenced (p < 0.01) the RT. Ewes on day grazing had higher (p < 0.01) RT compared with those on night grazing. Season had a statistically significant (P<0.01) effect on both RR and RT, showing different trends during the seasons of the year. RR values increased significantly in rainy season more than in summer and winter. With regard to the effect of season it was confirmed that the highest RT values were observed in summer, followed by rainy season and winter, correspondingly Copy Right, IJAR, 2017,. All rights reserved.