Background: As HIV/AIDS has emerged to be the first modern pandemic with ever increasing prevalence globally, the present study was undertaken to study the renal profile in patients living with HIV/AIDS, not started on ART. Materials and methods: This was a hospital based observational study where 277 cases were studied in details with the aims and objectives of studying the renal manifestations in ART naïve patients with HIV/AIDS and its relationship with CD4 counts. A detailed history, clinical examination and relevant investigations were done in patients above 15 yrs of age who were not on ART. Results: Out of 277 seropositives, 40 had proteinuria (14.44%) on urine examination. The mean serum creatinine of the total study population was found to be 0.92±0.83 mg/dl while 14 cases (5%) had serum creatinine more than 1.5mg/dl. A decrease in eGFR (<60ml/min/1.73m 2) was seen in 28 (10.1%) cases. Out of 178 cases with CD4 count more than 200cells/mm 3 , renal dysfunction was found in 12 cases (6.7%), whereas the cases with CD4 count less than or equal to 200cells/mm 3 , 19 out of 99 cases (19.2%) had renal dysfunction which is statistically significant. Conclusion: In the present study, which included ART naive patients with HIV/AIDS, predominant renal involvement was in the form of proteinuria followed by raised serum creatinine levels and reduced eGFR. A negative correlation was found between renal dysfunction and CD4 counts.