In search for new antioxidant agents derived from 6-azauracil, the spiro-5-(flurin-9'-yl)-6-azauracil 3 and their N,N-disubstituted-6-azauracils 4-17 have been synthesized using various methods and reaction conditions. Structure of the new synthesized compounds was deduced from elemental analysis and spectral measurements, for example IR, 1 H/ 13 C NMR and mass spectroscopy. The antioxidant evaluation of the new targets showed that the activity increases in the order of 8 > 10 > 6 > 7 > 9 in comparison with 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and ascorbic acid as standards.

Synthesis of new poly heterocyclic nitrogen systems containing 1,2,4-triazine moiety such as pyrazolines, pyrazolones, phthalazinone and 1,2,4-triazinone (9-17) have been deduced from hydrazinolysis of 3,5-dichloro-6,1-dihydro-1,2,4-triazine (2) which produced from the interaction between 6-azauracil (1) with POCl3/PCl5. Heterocyclization of 3,5-dihydrazino-1,2,4-triazine (7) by reaction nitrogen / oxygen / halogen bifunctional reagents in different mediums and conditions yielded the targets 9-17 respectively. Former structure of the products has been established from their elemental analysis and spectral data (UV, IR, 1H/13C NMR and Mass). All the new targets obtained evaluated as antioxidant probes in compare with ascorbic acid in 1,1-diphenyl-2-picrylhydrazyl (DPPH) as a standard, were the compounds 11>10>8>12>13 are more active probes.