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Lymphocytes from disease-free women and women with primary breast carcinoma were comparable vis-a-vis their capacity to inactivate breast tumor cells in vitro. Sera from comparable numbers of women in each of these two groups either blocked, potentiated or left unaffected the anti-tumor-cell cytotoxicity of their lymphoctes. As such, the results cast doubt on the validity of the hypothesis that there is a positive correlation between the presence of humoral blocking factors and in vivo tumor progression.

An attempt has been made to test the immunostimulation hypothesis of Prehn which proposes that, in its initial stages, the immune response to tumour-spec$c antigens stimulates rather than inhibits tumor growth. Mice have been injected with cells from three different methylcholanthrene-induced tumors and the cellular and humoral antitumor inimune responses of their peripheral blood lymphocytes and sera have been studied by in vitro techniques. The results have been found to be completely compatible

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