aspartate aminotransferase, alanine aminotransferase, or y-glutamyltransferase were transient and asymptomatic.We conclude that dexamethasone clearly improves the antiemetic efficacy ofondansetron for the control of acute nausea and vomiting after high dose chemotherapy with cisplatin. It Schayck. BM7 1991;303:1426-31 Bronchodilator treatment in moderate asthma or chronic bronchitis: continuous or on demand? A randomised controlled study Objective-To examine the effect of bronchodilator treatment given continuously versus on demand on the progression of asthma and chronic bronchitis and to compare the long term effects of a Pt2 adrenergic drug (salbutamol) and an antichoinergic drug (ipratropium bromide).Design-Two year randomised controlled prospective crossover study in which patients were assigned to one of two paraliel treatment groups receiving continuous treatment or treatment on demand.Setting-29 general practices in the catchment area of the University of Nijmegen.

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The effectiveness of high-dose testosterone undecanoate administered orally in suppressing spermatogenesis and eliciting the rebound-phenomenon was investigated in an uncontrolled clinical trial. Five men with fertility disturbances were treated for 10--12 weeks with 3 x 80 mg testosterone undecanoate daily. One patient achieved azoospermia and 2 oligospermia below 10 mill/ml, 1 suppressed to 27 mill/ml and 1 patient showed no effect. After cessation of treatment, 3 patients showed an increase in sperm concentration to greater than 50% of control values, one showed an increase of 35% and one showed a decrease in sperm count. The preliminary data suggest that although complete suppression of spermatogenesis is not uniformly achieved, a controlled study on the effects of high doses of testosterone undecanoate in male infertility may now by warranted.

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