This study reports that there are schizophrenics who do relatively well long term without the routine or continuous use of antipsychotic medication. Specially selected young males undergoing an acute schizophrenic episode were followed, after hospitalization, for up to three years. While hospitalized they were assigned randomly to either placebo or chlorpromazine treatment. Many unmedicated-while-in-hospital patients showed greater long-term improvement, less pathology at follow-up, fewer rehospitalizations and better overall function in the community than patients who were given chlorpromazine while in the hospital. Factors related to post-hospital outcome were good premorbid history and short-lived paranoid characteristics. Considerations which may have an effect on the successful management of acute schizophrenic patients not on medication are mentioned. The findings underline the need for further study of how to utilize antipsychotic medication more selectively in the treatment of schizophrenia.

Electroencephalographic averaged evoked responses to flashing lights of four different intensities were recorded in ten cats and correlated with behavior. Animals showing a high degree of exploratory behavior, aggressiveness, and activity and little withdrawal showed relatively large increases in amplitude of the averaged evoked response with increases of stimulus intensity. Those showing opposite behavioral traits had small increases or decreases of average evoked response amplitude with increases of stimulus intensity. These findings are compatible with those reported for human subjects. Inference is made about a neurophysiological mechanism for stimulus intensity modulation.

The differential effects of phenothiazine medication on auditory signal detection performance were compared in two types of schizophrenic subjects and in normal subjects. With increasing phenothiazine dosage a decrease in efficiency of signal detection performance occurred among nonparanoid schizophrenics and an increase in efficiency occurred among paranoid schizophrenics. These and related findings were interpreted in terms of differences in neuropsychological response and information processing characteristics in the two types of schizophrenics. The primary deficit in information processing in nonparanoid schizophrenics may be related primarily to their hypersensitivity to sensory stimuli, whereas in paranoids it may be related primarily to their impaired focusing of attention. Phenothiazines appear to decrease sensitivity to stimuli in nonparanoids but increase the ability to focus attention in paranoids. The possibility of treatment regimens which take into account the differential effects of phenothiazine medication was suggested.

Significant changes were found in two indices of the averaged visual evoked potentials in nine smokers after 12 and 36 hours of abstinence and after resumption of smoking. There was a decrease of the amplitude envelope accompanying withdrawal and an increase with resumption of smoking. These changes are consistent with the contention that tobacco increases arousal. Amplitude changes were found in a specific component of the evoked potential occurring between 100 and 125 milliseconds after the onset of the flash. The latter changes suggest the possibility that smoking selectively enhances the perceptiont of weak stimuli.