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In view of the paucity of data on the toxicity of fatty acids, experiments with oleic acid were zperformd. In control tests, olive oil was injected intravenously, and observations were made pertaining to fat embolism.The hemolytic effects of fatty acids are a well known phenomenon. This report deals with toxic manifestations observed in addition to those of hemolysis. The intravenous injection of fat emulsion was studied by a number of investigators such as Murlin and Riche;' Kochne and Mundel;2 Gordon and L e~i n e ;~ Clark and Br~nschwig;~ Dunham and Brunschwig ; McKibbin et d. ; Shafiroff and Frank ; LeVeen ; and reportedly by Russian workers who used human fat. Johnson et aLg-ll have demonstrated in-* Aided by a grant from the Otto Baer Fund. The Department is in part supported by the

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The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

In acute experiments with anesthetized dogs, the intravenous injection of medium and large doses of glucagon produced a triple modification in pancreatic juice secretion. The secretion rate was first transiently augmented, then was distinctly and persistently depressed, then finally returned to control values. The initial acceleration in secretion corresponded to the greatly increased arteriovenous blood sugar differences produced by the glucagon. The subsequent depression in secretion usually began while the A-V differences were still elevated. Return of secretion to control values coincided with return of A-V blood sugar differences to control values.