Alzheimer’s disease is a life-threatening neurodegenerative disorder. About 50 million people across the globe are affected by this disease. At final stages, this disease causes patients to lose cognitive ability, memory, and brain cells to the point of being totally dependent on other individuals for livelihood. The incidence of this disease is increasing across the world in the recent years, making the need of a better drug an urgency. Existing drugs show various side effects and natural sources of medicinal drugs are being explored. In this study, we explore the activity of natural compounds isolated through GC–MS analysis from the haustoria of palmyra palm against two major Alzheimer’s disease-causing enzymes, β-secretase and acetylcholinesterase. The binding affinity of these compounds against the target proteins and their pharmacokinetic properties were checked. Among the 37 compounds docked, 5 compounds showed good binding affinity and pharmacokinetic properties. These natural compounds showed a potential as a drug against Alzheimer’s disease. Further research is needed to study the synergistic activity of the compounds in live cells.

Background: Seaweeds and its derivatives are extensively used as biostimulants in horticulture and agriculture as a replacement for chemical fertilizers. G. edulis and G. acerosa are easily cultivable and economically important seaweeds. They are a rich source of phytohormones, amino acids, antibiotics, vitamins, micro, macro elements and agar. Such natural products have great demand and been commercialized these days to promote sustainable agriculture. Dried and finely powdered algal biomass is used directly as a biostimulant. Algal polysaccharides such as agar can be an innovative alternative to synthetic polymers used in horticulture as they contain active biostimulant compounds and also reported to hold water in the soil that aids plant growth with minimum water consumption than usually required. A. aritis being one of the most consumed leafy vegetables throughout the world can be harvested indoors with added nutrients and minimal water utilization.Methods: The field trial is a comparative evaluation of the two selected species of agarophytes for promoting plant (A. aritis) growth and the extracted agar tested for germination tests, bio-stimulatory property under water stress. Growth parameters were recorded after three weeks. The agarophytes were also qualitatively screened for phytochemicals and WD-XRF analysis.Result: The present work will be a supplementary contribution for assessing agarophytes with biostimulant properties and the characteristic agar gels that expand plant tolerance to abiotic stresses, thus constituting an alternative to synthetic plant protection products.

Alzheimer’s disease is a life-threatening neurodegenerative disorder. About 50 million people across the globe are affected by this disease. At final stages, this disease causes patients to lose cognitive ability, memory and brain cells to the point of being totally depend on other individuals for livelihood. The incidence of this disease is increasing across the world in the recent years, making the need of a better drug an urgency. Existing drugs show various side-effects and natural sources of medicinal drugs are being explored. In this study, we explore the activity of natural compounds isolated through GCMS analysis from the haustoria of palmyra palm against two major Alzheimer’s disease-causing enzymes, β-amyloid and Acetylcholinesterase. The binding affinity of these compounds against the target proteins and their pharmacokinetic properties were checked. Among the 37 compounds docked, 5 compounds showed good binding affinity and pharmacokinetic properties. These natural compounds showed a potential as a drug against Alzheimer’s disease. Further research is needed to study the synergistic activity of the compounds in live cells.