No abstract

In the protection of large groups of men by typhoid vaccination, it has been customary to avoid giving the vaccine to those having active tuberculous lesions and often, also, to those with latent forms of tuberculosis. The reason for this has presumably been the dread of the effect of any febrile reaction or of any temporary lowering of resistance in the tuberculous patients and also the reported exacerbations of tuberculous lesions following attacks of typhoid fever. On account of the few cases of tuberculosis which have been injected with typhoid vaccine and because of the confusing complexity of conditions often found in clinical work, it has seemed of value to observe the effect of typhoid vaccination upon susceptible animals which had been inoculated with active tubercle bacilli. The preliminary experiment of this series was made on two guinea-pigs of approximately the same age and weight.