Our aim was to assess the effectiveness of neonatal treatment of Rh hemolytic disease with high-dose intravenous immunoglobulin (HDIVIG), in reducing neonatal hemolysis. A total of 40 neonates born to isoimmunized Rh negative women were studied. The population was randomized into 2 groups: Group 1 received IVIG 800 mg/kg/day for 3 days, plus phototherapy; and Group 2 received only phototherapy. No significant difference was observed between the groups in the severity of either the antenatal and neonatal disease, mode of delivery, mean birthweight, gestational age at delivery, proportion of preterm deliveries, 1 minute Apgar Score, days of phototherapy, and presence of neonatal cholestasis. Group 1 babies showed a significantly decreased duration of hospitalization, less hemolysis, and a less marked increase in bilirubin levels on the first day of life than Group 2 newborns. Therefore, Group 1 neonates received less treatment with transfusions (exchange-transfusions and/or simple blood treatment with transfusions) than those in Group 2. Our data suggest that the frequency of transfusional therapy can be reduced by combining conventional phototherapy with HDIVIG. Further studies are needed to determine the optimum timing and dosages of neonatal HDIVIG treatment.

H O I P I I~~. B Y~~O S~l r e s , A r g e n r l n a obleflue t o dererm>ne r h e ~n c~d e n c e o f ENS ~n c h l l d r e n born m o r e t h a n 2L h i a i r e r PRM, and 1 0 e v a l u a r e t h e d l a g n o r t l c r e l l a b > l l r y o f 3 r e i r r a l t e r n a r l v e r o b l o o d c u l t u r e , namelv c u l t u r l n o e x t e r n a l a u d > o v e c a n a l 1EAC) ruab. n a r a~h a r v n o e a l a i o > r a t e (NPII) and g a s t r 1 c arplrare 1Gh). . Blood c u l t u r e war p e r i a r m e d u > r h l n t h e f~r r t 3 h o u r s of l l f e and EAC. NPA and 64 c u l t u r e s and b~i t h ENS uar c o n r~d e r e d p r e s e n t uhen c l l n r c a l m a n~f e r t a t ? a n r o f i e p s l r v e r e e u > d e n r u~i h > n t h e t > r r r A8 h i and b l o o d c u l t u r e proved ~o r~i l u e Newborn f r o m motherr on p r i o r a n r > b l a t l c t h e r a p y were e x c l u d e d 1101146) u l r h p r e t e r m b , r t h ~r o l a r e d = r a n p o r i r , u e m~i r a o r g a n~r m s v e r e s a u r e u r ( n = 9 ) , s pneuma-nlae ( n = 3 ) , s " > r~d a n r ( n =~) , p n t e r o c o c i u r l n = l ) and L m o n r i y r o g e n e i ( n = l ) .~r a m n e g a i~v e were K pneumon;ae l n = 5 ) . E c o t , l n = 2 ) and H ~n f l u e n l a e l n = l ) D~stance standars for height were constructed on a sample of 254 girls with T.S.. with different cariotypes (47% XO. 53% other types) and treated with oestrogens during puberty from a mean age of 13.98 yr. (SD 2.0). Patients were measured at intervals ranging from 0,5 to 1.5 years dur~ng 1 to 11 years at the division of Endocrinology Htal R. Gutierrez..Fiflieth centile was estimated by adjusting a 5 degree polynomial to the mean height obtained at each 0.5 year interval. Residual SD of the fitting was very low (0.8 cm ). First derivative of the median distance curve showed that adult he~ght (height velocity less than 0.2 cmlyear) is atta~ned at 18.2 yr. Mean adult height was 137.9 cm. with SD of 5,7 cm , very similar to the SD found in healthy argentine female population. Chi Square test for d~fferences between distribution of raw date among selected centiles and theoretical expected distribution was not significant The differences between adult height of local Turner girls and adult height of Turner girls from other population are similar to the population differences between normal girls Voto, M.Margulies. Neonatology Unit, Obstetrics Division, J u a n A.Fernandez Hospital, Buenos Aires, Argentma.Introduction: S e v e r e anti-D hemolytlc disease c a r r i e s a high n s k of fetal a n d neonatal moribiditv a n d mortalitv. ~a t e r $ l & ~k h o d s : A total of 30 neonates were studied. The level of hemoglobin a n d bilirubm at birth, t h e p r e s e n c e of h y d r o p s fetalis, a n d t h e need f o r mechanical ventilation a n d c o r r e d l o n of hematohqic -~~ parameters were assessed. Results: Hydrops fetalis was p r e s e n t i n 8 c a s e s (27%). Mean gestational a g e d e l i v e r y was 33.42 weeks, a n d mean b~h w e i g h t was 2017t348 g. I...