Papillary thyroid cancer (PTC) is one of the generic types of thyroid cancer and most prevalent form of malignancy among all cancers of the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC constitutes approximately 85% of all thyroid cancer cases. PTC is usually contained within the thyroid gland and generally biologically indolent. The present article provides an updated condensed overview of PTC, which focuses mainly on the molecular and biomarker investigations.