In this era, the identification or synthesis of a new antibiotic is important research due to the pollution and harmful bacterial pathogens. Hence this work selected the already known mild active molecules such as Nicotinamide and Thiazole to enhance the activity against the disease-causing pathogens. Using peptide coupling reagent EDCI, nine compounds were prepared and characterized by 1 H NMR, Mass spectroscopy. The characterized compounds were evaluated In vitro antibacterial and antifungal activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumonia, Candida albicans by broth dilution method and zone of inhibition measured in millimeter. All the derivatives showed good to moderate activity. Out of nine compounds N- (4-(thiomorpholine-4-carbonyl) thiazol-2-yl) nicotinamide showed better zone of inhibition between 27 mm and 34 mm. the outcomes of the result revealed that the diamide bond acts as an important pharmacophore and exposed the good inhibition behavior.

Identification of a novel antimicrobial molecule is vital to research due to contaminated agro related products and injurious pathogens. Especially candida albicans is most common infective fungi in the present world, that cause hospital-acquired infections. There is a medical and biological need for the discovery of novel antimicrobial drugs with high potent in nature. This effort involved the synthesis of scaffold molecule, in which Vitamin B3 and oxazole plays vital role as pharmacophore moiety, where 2-(Nicotinamido) oxazole-4-Carboxylic acid coupled from pyridine–3-carboxylic acid (Nicotinic acid) and 2-aminooxazole derivative. Then it is characterized by mass spectra, 1H NMR spectroscopy and carried for the growth control ability study against microbial targets such as fungal, and bacterial targets. The Zone of inhibition measured in millimeter for the serially diluted solution of the compound. From the outcomes, the compound (5i) displayed 35mm of inhibition zone area but standard fluconazole showed 29mm for 250 ppm solution. The outcome revealed that the amide bond and oxazole moiety turns as imperative pharmacophore besides showing decent inhibition activities.

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