Granulomatous gastritis (GG) is a subtype of chronic gastritis which may be infectious, non-infectious, or idiopathic in nature. For treating clinicians, granulomatous gastritis has always been a diagnostic challenge because of the same clinical and endoscopic features between Crohn’s disease and tuberculosis. A diagnosis can be reached only by the combination of histopathological examination with clinical and laboratory investigations. Several studies showed that granulomas are more common in the antrum and are generally located superficially within the gastric pit where the gastric bacteria H.pylori are seen, which can cause damage. We are reporting two rare cases of granulomatous gastritis associated with H.pylori in a 40-year-old male and a 43-year-old female with a negative family history of tuberculosis.