No abstract

Purpose To assess the ability of a novel imaging device to allow physicians to personalize therapeutic regimens based on objective patient drop administration data. Methods A novel imaging system was used to record video of the drop technique of subjects in clinic (n = 25) or at home (n = 17) for 1 week. Video assessment by a reading center was compared with patient reporting and their prescribed regimen with respect to how many drops were applied and how many landed in the eye. Results Reading center assessment of both drops dispensed and drops landing in the eye was significantly different from the prescribed regimen in the clinic (P d = 0.005, P i o0.001, respectively) and at-home arms (P d = 0.003, P i o0.001, respectively). Conclusions This imaging system is a powerful tool to help physicians tailor patient therapy more accurately, to help researchers evaluate new drop therapies with objective rather than subjective data, and to potentially facilitate better patient training for improved drug delivery.

Identification of two independent QTLs that could affect expression of the HCG22 mucin gene product via two different mechanisms (transcription or secretion) is highly suggestive of a role in steroid-induced OH.

We evaluated the toxicity of very low viscosity (100 centistokes) and higher viscosity silicone oil (5000 centistokes) in rabbit eyes as a short-to-long-term postoperative vitreous substitute (6 weeks to 5 months). Emulsification of 100-cs and 5000-cs silicone oil did not occur in eyes which were followed for as long as 5 months. No toxic effects to retinal cells were detected by light or electron microscopy. Because no toxic effects were seen with 100-cs silicone oil, it can be used in an outpatient setting as a short-term postoperative tamponading agent. Electroretinographic responses of silicone-injected eyes were normal.