No abstract

We investigated the potential of aspirin and dipyridamole in combination to inhibit thrombus formation by comparing endarterectomized segments of 20 dog carotid arteries in animals treated with pre- and post-operative aspirin and dipyridamole to 20 arteries from untreated animals and 20 arteries from animals receiving intra-operative heparin. The temporal profile of thrombus formation was assessed by means of angiography, light microscopy, and scanning electron microscopy at time intervals ranging from 30 minutes to three months from the time of surgery. All of the aspirin-dipyridamole vessels remained patent and only one had significant gross thrombus formation. This contrasted to six occlusions and six significant gross thrombi in the control group and one occlusion and six significant gross thrombi in the heparin group. The combination of oral aspirin and dipyridamole minimizes thrombus formation in the highly thrombogenic lesion created by carotid endarterectomy in the dog.

Background: Around 130-170 million individuals are thought to be affected with the hepatitis C virus (HCV), which is a viral pandemic and the leading cause of persistent liver illness. The frequency of HCV infections is greatest in Egypt, where more than 10% of the general population is affected. Objective: The purpose of the current study was to confirm any potential associations between cirrhosis and the XRCC1 rs25487 variant in chronic HCV patients. Patients and methods: A fibroscan was conducted on 80 HCV +ve patients and 40 control participants for a total of 120 people to determine the extent of hepatic fibrosis. Real-time PCR was used to examine the SNP genotyping in the XRCC1 gene (rs25487). Results: There were no substantial variation in the prevalence of different genotypes in XRCC1 A > G (GG and AG) between non cirrhotic and cirrhotic in chronic HCV Egyptian patients. Conclusion: By comparing the incidence of the various genotypes (AA, AG, and GG) in the analyzed groups, no clear pattern of relationship could be seen (p=0.225). (P = 0.410) There was no distinguishable pattern of connection between the AA genotype and the other genotypes (GG and AG). Comparing the frequencies of the two alleles (A and G alleles) in the three groups under study revealed no evidence of a connection.