Background: Gender determination is an essential issue in forensic medicine. It is one of the deceased person identification data that could not be easily elucidated in several conditions as road traffics and mass disasters. Maxillary sinus is characterized by being intact even with skull disfigurement. Aim of the study: assessment of the maxillary sinus dimensions as measured from CT scan and evaluation of its potential efficacy in sex determination. Patients and methods: 64 patients attended the radiology department Al-Demerdash hospital, Ain Shams University for paranasal sinuses computerized tomography (PNS CT scan) were the subjects of the study. CT scan was performed and maxillary sinus dimensions were obtained. Results: no statistically significant difference was found between both genders regarding the maxillary sinus dimensions. Conclusion: The current study did not validate the use of maxillary sinus dimensions in sex determination among Egyptian individuals.