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The present study was designed to investigate the Comparison of therapeutic effect between, some sulphur amino acids and drugs Oroxin on β amyloid-induced Alzheimer's in obese rats .Twenty of female rats of Sprague Dawley (weighting 200±10 g) were divided into two main groups Group (1) negative control (-ve) (5 rats). Fifteen rats were fed on the high fat diet and administered aluminum chloride for 6 weeks to induce obesity and Alzheimer and reclassified to three groups (5rats each). Group (2) positive control group (+ ve) Group (3) treated with methionine and cysteine (4.5 g/100 g protein) group (4) treated with orexin drug (OxA) (20 mg/kg b.w.t). The study period was set for ten weeks (six weeks to injury of obesity &Alzheimer's and four weeks for treatment).The results revealed that there was a significant decrease in body weight gain, weight gain percent and FER among all rats group which treated with sulpher amino acids and orexin, in comparing with positive control group. Moreover, The treatment rat groups showed significant decrease in body weight gain, food intake, Food efficiency ratio (FER):, Body mass index (BMI), serum ALT, AST , ALP, Creatinin Uric Acid Urea ,cholesterol, triglyceride, low density lipoprotein cholesterol(LDLc),very low density lipoprotein cholesterol (VLDLc), total lipids (T. Lipids) , phospholipids, brain levels of malondialdehyde (MDA),B-amyloid and serum aluminum chlorid but showed significant increase in serum high density lipoprotein cholesterol (HDLc), brain catalase (CAT), glutathione-S-transferase (GST) and superoxide dismutase (SOD) compared to positive control group. The biochemical analyzes agreed with the histological examination of brain tissue It can be recommendation that the consumption sulphur amino acids could lowering of body weight gain and improvement of biochemical parameters and brain degenerative histopathological changes as the orexin drug