No abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders of women in the childbearing period. However, its pathophysiology is still unclear. Certain polymorphisms of the luteinizing hormone/choriogonadotropin receptor (LHCGR) genes may lead to changes in the bioactivity of this hormone. The important functional role of LHCGR in the metabolism of androgen and ovulation, the LHCGR gene variant, may be related to the risk of PCOS. AIM: The aim of this study was to evaluate the association between LHCGR Ins18LQ gene polymorphism and PCOS. METHODS: A case–control study was performed in women with PCOS and non-PCOS from May 2019 to October 2019 in HFC IVF Center. We included 50 women with PCOS and 50 healthy controls. Polymorphism of the LHCGR (ins18LQ) gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism. RESULTS: From this study, we found that there was no significant difference in the proportion of ages between the groups (p > 0.05). There were significant differences in the characteristics of body mass index, FSH level, LH level, and LH/FSH ratio between the PCOS and control groups (p < 0.05). We also found that the proportion of heterozygote variant non-ins/ins was higher in the PCOS group compared to the control group, but there was no significant difference between the polymorphisms of the non-ins and non-nonins variants between the PCOS and control groups (p = 0.269). The frequency of ins alleles was higher in the PCOS group compared to the control group. CONCLUSION: There was no significant association between LHCGR ins18LQ gene polymorphism and PCOS.

Pendidikan merupakan salah satu komponen penting untuk mencapai kesejahteraan. Pendidikan dapat menunjang kualitas sumber daya manusia yang pastinya berdampak akan kemajuan suatu bangsa. Meninjau hal ini, penting untuk menumbuhkan dan meningkatkan semangat belajar anak sejak dini. Berbagai upaya dilakukan untuk menumbuhkan semangat belajar anak-anak termasuk anak di Panti Asuhan Cinta Kasih Medan. Terlebih banyak dari mereka yang lebih senang bermain dan kurang memiliki semangat bersekolah apalagi minat untuk belajar, terkhusus bagi mereka yang berusia dibawah 10 tahun. Melalui kegiatan Praktikum 1 yang dilaksanakan sejak bulan Maret hingga Mei tahun 2022, penulis melakukan mini project terhadap salah satu anak di Panti Asuhan Cinta Kasih Medan. Kegiatan ini dilakukan dengan menggunakan metode casework dengan tahapan secara general yang meliputi Engagement Intake Contract, Assessment, Perencanaan, Intervensi, Monitoring dan Evaluasi, serta diakhiri dengan Terminasi. Adapun tools yang digunakan dalam assessment yakni tools ecomap yang membantu dalam menemukan sumber-sumber masalah dan sistem pendukung untuk mengatasi masalah yang dialami klien. Setelah melalui proses dengan menggunakan tahapan dan tools tersebut, tujuan untuk menumbuhkan dan meningkatkan semangat belajar anak di panti terbukti tercapai. Tentunya hal ini akan berpengaruh besar terhadap perkembangan di dalam diri klien. Klien termotivasi untuk terus belajar di sekolah maupun panti dengan metode-metode yang menyenangkan.

Ninety-four children of the Tobacco Plantation Laborers of the PTP IX,aged between 2 months and 12 years, were investigated on erythrocyte sedimen tation rate with the micro ESR method.

Village life around the forest is inseparable from the existence of the forest. The use of raru as a forest product has been passed down from generation to generation in the community of Bonalumban Village, Tukka District, Central Tapanuli Regency, North Sumatra. The study of community perceptions and dependencies on Raru in Bonalumban village is needed to determine the potential of raru and encourage efforts to preserve raru. The method of selecting respondents is done by purposive sampling by selecting general respondents and specialized respondents. Data analysis uses descriptive statistics. Public perceptions about the existence of raru in nature are still plentiful so there is no public effort to regenerate. Community dependency on raru is grouped into four categories, that is for sale, palm wine concoctions, animal cages, and building materials. Raru harvesting activities by felling without being accompanied by cultivation activities causes the presence of raru vegetation to decrease.