IntroductionThe first line of defence is the skin, preventing foreign things from entering the human body system and preventing water loss from the body via evaporation 1,2) . The stratum corneum is a complex outermost layer of the skin that acts as the initial physical barrier to any external elements, including medicines, entering the body, which also makes an obstacle in the drug penetration into the body 2) . However, owing to its simple and convenient accessibility, the skin remains an appealing route of drug administration,

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Metal complexes Mn(II), Co(II), Cu(II), Zn(II) and Ag(I) of the ligand 1,6-bis(1-benzimidazolyl)hexane were synthesized by the reaction of the ligand and appropriate metal salts in l: 1 mole ratio. The ligand and its complexes were characterized using IR, Uv-Vis, 1H and 13C NMR, Mass spectroscopy, and elemental analysis CHN. Depending on the abovementioned techniques, a polymeric structure was proposed to the prepared complexes. Further, all the synthesized compounds were tested against some of the soil-borne fungi namely; Rhizoctonia solani, Fusarium oxysporum, Fusarium solani and Pythium aphanidermatum. The results showed that the tested compounds have an effect on the growth of pathogenic fungi. This leads to thinking that these compounds could be used one day as new chemical pesticides as an alternative to chemical compounds that have been shown to be resistant to pathogens.