No abstract

Effectiveness of many antibiotics has been remarkably decreased due to bacterial resistance. the present work aims to explore a novel antimicrobial nanocomposite with greater efficacy against resistant bacteria. Tobramycin-silver nanocomposite was synthesized and characterized by Transmission Electron Microscopy, UV-VIS Spectroscopy, Zetasizer and Fourier Transform Infrared spectroscopy. Antimicrobial activity of tobramycin, silver nanoparticles and Tobramycin-silver nanocomposite was tested against Staphylococcus aureus, pseudomonas aurignosa, Klebsiella pneumonia, Proteus mirabilis and acinetobacter bauminaii, the results revealed that Tobramycin-silver nanocomposite had enhanced antimicrobial efficacy against the selected resistant strains in range between 250% and 980% than Tobramycin alone.

The Red Sea can provide a sustainable solution to combat bacterial resistance. The contribution of this work is that B. amyloliquefaciens was isolated from Heteroxenia fuscescens, Red Sea, Egypt. Moreover, the bacterial extract showed a broad spectrum with a potent antimicrobial activity.