Aim: Regardless of medical advancements, ectopic pregnancy (EP) is still an essential factor in the mortality rate of women of reproductive age. The main aim of this study was to determine predictive factors associated with the success of the response to treatment with single-dose and two-dose methotrexate (MTX) regimens in women with tubal EP. Material and Method: This retrospective study examined the electronic records of 130 patients who underwent treatment due to EP were included in the study. The patients were divided into two groups: the successful MTX treatment group (n: 85) as the case group and the failure of MTX treatment group (n: 45) as the control group. Results: Age-matched (30.62±4.36) and body mass index (BMI)-matched (24.37±2.29) patients diagnosed with EP were treated with MTX. The mean beta-human chorionic gonadotropin (β-hCG) value on the first day of treatment was 1639.84±524.96 mIU/mL in the successful and 5866.76±1875.51 mIU/mL in the unsuccessful group. 85 of 130 (65%) were successfully treated with MTX. Five of 45 (35%) failed medical treatment and required laparoscopic surgery. The longest ectopic mass diameter was significantly higher in the failure of MTX treatment group (p

Aim: The study aims to retrospectively evaluate the laparoscopy results of patients who underwent laparoscopy with chronic pelvic pain (CPPS) diagnosis in two groups of fertile and infertile patients. Material and Method: This retrospective study examined the electronic records of 170 patients who underwent laparoscopy due to CPPS were included in the study. The patients were divided into two groups: the CPPS and unexplained infertility group (n: 87) as the case group and the CPPS fertile group (n: 83) as the control group. Women aged 25-40 years with unexplained infertility and CPPS were included in the study. Results: Results found a statistically significant association between infertility in women and laparoscopy results (p0.05). There was no statistically significant association between women’s infertility and smoking status (p>0.05). Mann-Whitney test did not find a statistically significant association between case and control regarding age and body mass index (BMI) (p>0.05). There was a statistically significant difference between groups in terms of the duration of pain (p

Aim: The aim of this study was to investigate the relationship between thyroid autoantibody and first-trimester aneuploidy results. Thyroid autoimmunity (TAI) is the most common autoimmune disorder. Patients with TAI are usually euthyroid. Thyroid peroxidase (TPO-Ab) in patients with or without thyroid dysfunction is associated with infertility, recurrent embryo implantation failure, and early pregnancy loss. The impact of TPO-Ab on first-trimester aneuploidy test results needs to be studied. Material and Method: This retrospective case-control study was conducted between December 2019 and May 2022. Patients with thyroid autoantibody positivity (n=112) were included in the study as the case group. The control group was selected from age and body mass index (BMI)-matched patients (n=130). Nuchal translucency (NT), crown rump length (CRL), pregnancy-associated plasma protein A (PAPP-A) and free beta subunit of human chorionic gonadotropin (β-hCG)) values were compared between the two groups. Results: This study included two hundred forty two age-matched (29.86±4.51) and BMI-matched (23.96±2.34) women. There was no statistically significant difference between groups in terms of free thyroxine (FT4), PAPP-A and free β-hCG (p>0.05). NT as a marker for major chromosomal defects and CRL were comparable in case and control groups (p>0.05). Conclusion: There is no statistically significant relationship between thyroid autoimmune diseases and the first-trimester aneuploidy results.

Aims: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women. Hyperinsulinemia and insulin resistance (IR) are the most important metabolic abnormalities that affect these patients. This study aimed to investigate the variables related to IR in patients with different PCOS phenotypes. Methods: This retrospective study included 389 women diagnosed with PCOS in Bezmialem Hospital between november 2020 and september 2022. Information about patients was collected through their electronic records. PCOS was diagnosed based on the Rotterdam criteria, and four phenotypes of A (oligoovulation+ hyperandrogenism+PCO), B (oligoovulation+hyperandrogenism), C (hyperandrogenism +PCO), and D (oligoovulation+absent PCO) were considered for PCOS. The homeostatic model assessment for ınsulin resistance (HOMA-IR) was used to evaluate IR. The Mann-Whitney U test was performed to study the difference between the groups. Results: The highest value of HOMA-IR was for the phenotype B group, and the lowest value was for the phenotype C group. However, the difference between the groups was not significant (p=0.221). Estradiol and free T4 were significantly higher in the phenotype A group (p≤0.001). Thyroid-stimulating hormone (TSH), prolactin, anti-mullerian hormone (AMH), fasting insulin, total testosterone, and red blood cell distribution width (RDW) were significantly higher in the phenotype B group (p≤0.001). Total cholesterol, high density lipoprotein (HDL), leukocyte, basophil, and monocyte were significantly higher in the phenotype C group (p≤0.001). Also, MPV values were significantly higher in the phenotype D group (p≤0.001). Conclusion: The results showed that the variables related to IR in phenotypes A and B of PCOS are higher than in other phenotypes.