ABSTRAK
BNP utamanya disekresi oleh ventrikel jantung sebagai respon peregangan atau tekanan dinding ventrikel kiri yang terjadi pada pasien gagal jantung. Peningkatan kadar NT-proBNP berhubungan dengan derajat keparahan gagal jantung dan ejeksi fraksi ventrikel kiri. Beberapa penelitian klinis membuktikan modulasi neurohormonal pada sistem RAAS menurunkan nilai NT-proBNP August-November 2015, 13 patient (38-63 years, 6 woman, 7 men)
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