ANALYSIS OF CHANGES IN THE SERUM LEVEL NT-proBNP AFTER ACE INHIBITORS THERAPY IN PATIENTS WITH HEART FAILURE

Hartoto, Halla Hisan; Zulkarnain, Bambang Subakti; Aminuddin, Muhammad

doi:10.20473/fmi.v52i3.5451

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…These results are in agreement with two previous studies conducted in Indonesia. 14,15 On the contrary, a study in Scandinavia stated that prevalence of elderly heart failure patients based on gender is almost similar, but it was slightly higher in female patients. 2 Likewise, a study in Italy showed that both sexes were almost same, but it was slightly higher in women.…”

Section: Discussionmentioning

confidence: 98%

N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure

Marfianti

Fauziyati

Hisyam

2020

JKKI

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Background: Heart failure is a major health problem in the world. It is associated with high morbidity and high mortality especially in elderly patients. Most studies reported that N terminal pro-B type natriuretic peptide (NT-proBNP) is used in the diagnosis of heart failure, but tests in determining severity levels of heart failure in the elderly remains unclear.Objective: This study is to determine differences of NT-pro BNP levels based on severity of heart failure in elderly patients. Methods: This was an observational study with a cross sectional design. Its subjects were patients with heart failure and age of ≥ 60 years. Patients were divided into two groups: mild and severe heart failure groups according to severity of heart failure based on New York Heart Association (NYHA). The NT Pro-BNP levels were measured for all subjects in both groups. All obtained data was analysed by using unpaired t test and was considered significant if p <0.05. Results: This study involved 24 subjects. The mean age of the subjects was 64.50 ± 4.65 years with a minimum age of 60 years and a maximum age of 78 years. The NT pro-BNP levels in the severe heart failure group (1.2587.58 ± 574.85 pg/ml) was higher than the mild heart failure group (867.83 ± 333.27 pg/ml), andit was statistically significant with p = 0.040. Conclusion:The levels of NT-pro BNP serum in the elderly patients with severe heart failure (NYHA III-IV) were significantly higher than in patients with mild heart failure (NYHA I-II).

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Section: Discussionmentioning

confidence: 98%

N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure

Marfianti

Fauziyati

Hisyam

2020

JKKI

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Comparison of Concentration Difference between ST2 and NT-Pro BNP Before and After Ace-Inhibitors in NYHA III-IV Hearts Failure Patients

Maskito¹,

Anniwati²,

Aminuddin³

2019

Indonesian J. Clin. Pathol. Med. Lab.

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Background: The American Heart Association (2016) stated that at the age of forty the risk of developing heart failure is one in five. Medication is based on clinical signs and symptoms that are often late. Early cardiac markers are required to guide therapy. This study compared the difference between ST2 and NT-ProBNP concentrations before and after ACE inhibitors (ACE-I) in NYHA III-IV heart failure patients.Method: This was a randomized prospective observational study without controls. The respondents were males or females, 21-75 y.o in NYHA III-IV heart failure patients. Twenty-five respondents were appropriate to inclusion criteria. The ST2 was measured by Quantikine®ST2/IL-33R quantitative sandwich ELISA immunoassay while NT-proBNP was measured by Immulite Turbo® 1000.Result: Majority of respondents were males (60%) and had comorbidities(60,7%), consisting of NYHA Class III(36%) and IV(64%). Coronary artery disease and valvular heart disease (40%,36% respectively). Length of stay was 6.4±3.4days. The concentration difference of ST2 and NT-proBNP before and after ACE-I were both significant, however, NT-proBNP was more significant (p=0,001 vs p=0,023). NYHA at admission influenced ST2 difference but not NT-proBNP. NT-proBNP concentration correlated to length of stay while ST2 was not. ST2 had negative correlation with age, no correlation to GFR and weight. NT-proBNP was correlated to weight, negatively correlated to GFR, not correlated to age. ACE-I subtypes difference did not affect the study result.Conclusion: NT-proBNP was a better heart failure cardiac marker than ST2 due to its ability in diagnosis, prognosis and showing more significant difference after ACE-I administration.

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ANALYSIS OF CHANGES IN THE SERUM LEVEL NT-proBNP AFTER ACE INHIBITORS THERAPY IN PATIENTS WITH HEART FAILURE

Cited by 2 publications

References 10 publications

N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure

N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure

Comparison of Concentration Difference between ST2 and NT-Pro BNP Before and After Ace-Inhibitors in NYHA III-IV Hearts Failure Patients

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