No abstract

Background. Typically, the step test is used to assess the physical performance that is determined by the condition of the cardio-respiratory system. The latter, in turn, is associated with the nervous, endocrine and immune systems, which collectively determine the level of adaptation of the body. The purpose of this study is to analyze the effect on the step test of natural adaptogens and associated changes in a number of parameters of cardio-respiratory, autonomic nervous and immune systems and metabolism. Material and methods. The target was 80 children of both sexes, ages 10-17, arriving at the clinical sanatorium "Dzherelo" of Truskavets spa from radionuclide contaminated territories. The main subject of the study was the Popovych's step test. State of autonomous nervous and immune systems was assessed as well as others functional and metabolic tests. Results. The contingent surveyed was retrospectively divided into three qualitatively distinct groups. The largest group (53,7%) was the group of children with initially reduced or normal levels of Popovych's Step Test Index (PSI), in which it increased. However, in 28,8% of children PSI remained stable at different initial levels, and in 17,5% even decreased, without falling below the lower limit of normal. Discriminant analysis was subsequently applied to identify constellations of parameters that change are characteristic of each cluster. The program selected as characteristic changes in 2 parameters of autonomous nervous system, 2 functional, 4 metabolic and 3 immune parameters as well as blood trombocytes level. The correct classification of the positive actotropic effect is 93,0%; neutral 65,2%; negative 64,3%, and total correctness is 80,0%. Conclusion. Balneotherapy causes multivariate changes in Popopvych's step test, which accompanied by characteristic changes in certain parameters of autonomous nervous and immune systems as well as others functional and metabolic tests.

Background. Earlier, we found the multivariant nature of the Popovych's step test change in children after a course of adaptogenic balneotherapy. In particular, the step test improved in 53,7% of children, remained unchanged in 28,8%, and worsened in 17,5%. The purpose of this study is to identify predictors that allow us to forecast each variation of the step test. Material and methods. Object of observation was 80 children of both sexes, ages 10-17, arriving at the clinical sanatorium "Dzherelo" of Truskavets' spa from radionuclide contaminated territories. The main parameter of the study was the Popovych's step test. State of autonomous nervous, endocrine and immune systems was assessed as well as others functional and metabolic tests. Results. Discriminant analysis was subsequently applied to identify constellations of parameters-predictors of each variant of change in step test. The program selected 16 initial parameters as predictors (primarily level of step test, next sex, body mass and temperature, levels of Gench's and Teslenko's tests, vagal tone, erythrocytes sedimentation rate, trombocytes level as well as 7 immune parameters). The correctly of forecasting of the positive actotropic effect is 90,7%; of neutral is 78,3%; of negative is 92,9%, and total correctness is 87,5%. Conclusion. Balneotherapy causes multivariate changes in Popopvych's step test, which determined by constellation of 16 initial parameters.

Актуальність. Сьогодення характеризується швидким темпом життя, економічною нестабільністю, загостренням екологічних проблем, серед яких глобальні зміни клімату, забруднення довкілля, погіршення якості продуктів харчування, що призводить до зниження захисних функцій організму. При цьому активізуються окиснювальні реакції, у результаті яких в клітинах та тканинах організму накопичуються вільні радикали, які сприяють атеросклерозу, гіпертонії, ішемії, онкологічним та алергіч-ним захворюванням, передчасному старінню організму тощо. Антиоксиданти протидіють утворенню вільних радикалів. Природні антиоксиданти містяться у рослинній сировині. Найвищу антиоксидантну активність має рослинна сировина з високим вмістом фенольних та поліфенольних сполук, каротиноїдів, вітамінів А, Е, К і С [1, c. 6; 2, с. 9]. Для офіційної та народної медицини цінною рослинною сировиною є суцвіття Calendula officinalis завдяки значному вмісту біологічно активних речовин (БАР),

The article deals with the analysis of the existing methods of investigating the antioxidant activity of plants’ origin and the expediency of measuring oxidation-reduction potential for this purpose.The integral AOA of alcohol extracts Urtica dioica, Trifolium pretense, Chelidonium majus, Hippophae rhamnoides has been determined by potentiometric method using the mediator system. It was established that the leaves of sea – buckthorn are characterised by the highest antioxidant activity (2.05 ± 0.1 mg AA / ml). The АОА of plants Urtica dioica, Chelidonium majus, that were growing along the transport zone is higher by 23,1-27,9% comparing with the plants collected from environmentally friendly area. It was found out that the plants of Hippophae rhamnoides L. coriander were adapted to oil pollution, as evidenced by the absence of a significant difference between AOA of plants collected from environmentally friendly area comparing with the plants that were growing on the soil polluted with petroleum products.