No abstract

Novel peptidomimetics containing dithiocarbamate groups were synthesized via the Ugi reaction. Also, dithiocarbamates of natural amino acids were prepared and were used successfully in Ugi reactions to prepare novel peptidomimetics bearing amino acid and dithiocarbamate groups in a single structure. In addition the prepared dithiocarbamates based on amino acids are converted to the corresponding amides.

A simple, efficient, and regiospecific method for the synthesis of dithiocarbamates by the one-pot, three-component Markovnikov addition reaction of an amine, carbon disulfide, and N-vinylpyrrolidone is described.

N‐Vinylpyrrolidine reacts with dithiocarbamic acids, generated in situ, to give the target compounds as Markovnikov products.