No diseases are known to result from the lack of expression of ABO blood group antigens, but the susceptibility to a number of diseases has been linked with a person's ABO phenotype. A cross sectional study conducted at research laboratory of Gharb El-Niel College from May to August 2022, to estimate the relation of ABO blood group on fibrinogen levels and platelet count in apparently healthy Sudanese subjects.  For the A positive blood group there was significant decreased in the fibrinogen level when compared with the B⁺, O⁺ and O⁻ blood group, and in significant differences with the AB⁺ and A⁻. For the platelets counts; there was significant increased with AB⁺ and in significant differences with other blood groups, for the B⁺; there was significant decreased in the fibrinogen level when compared with other blood groups, however in the platelets count there was insignificant differences in all blood grouping except the  O⁺.  In addition, there was significant decreased in the fibrinogen level in O⁺ when compared with the AB⁺ and A⁻.  AB⁺ when compared with the O⁻, and A⁻ when compared with O⁻.   Regarding the platelets count there was significant differences when O⁺ blood group compared with AB⁺, and AB⁺ when compared with the A⁻ and O⁻. There were insignificant differences when the fibrinogen level and platelets count compared with the age and gender.  Finally, there was a clear significant decreased in the fibrinogen levels and platelets count among the individuals with different ABO blood group. Keywords: ABO blood group, fibrinogen, platelets, phenotype, coagulometer.