This article focuses on the design of transmitters and receivers for molecular communication (MC). It also reviews existing literature on transmitter and receiver architectures for realizing MC, including both nanomaterial-based nanomachines and/or biological entities.

Molecular communication (MC) is the most promising communication paradigm for nanonetwork realization since it is a natural phenomenon observed among living entities with nanoscale components. Since MC significantly differs from classical communication systems, it mandates reinvestigation of information and communication theoretical fundamentals.The closest examples of MC architectures are present inside our own body. Therefore, in this paper, we investigate the existing literature on intra-body nanonetworks and different MC paradigms to establish and introduce the fundamentals of molecular information and communication science. We highlight future research directions and open issues that need to be addressed for revealing the fundamental limits of this science. Although the scope of this development encompasses wide range of applications, we particularly emphasize its significance for life sciences by introducing potential diagnosis and treatment techniques for diseases caused by dysfunction of intra-body nanonetworks.

Information transmission in the nervous system is performed through propagation of spikes among neurons, which is done by vesicle release to chemical synapses. Understanding the fundamentals of this communication can lead to the implementation of bio-inspired nanoscale communication paradigms. In this paper, we utilize a realistic pool-based model for vesicle release and replenishment in hippocampal pyramidal neurons and evaluate the capacity of information transmission in this process by modeling it as a binary channel with memory. Then, we derive a recurrence relation for the number of available vesicles, which is used to find successful bit transmission probabilities and mutual information between input and output. Finally, we evaluate the spiking probability that maximizes mutual information and derive the capacity of the channel.

Bio-inspired molecular communications (MC), where molecules are used to transfer information, is the most promising technique to realise the Internet of Nano Things (IoNT), thanks to its inherent biocompatibility, energy-efficiency, and reliability in physiologically-relevant environments. Despite a substantial body of theoretical work concerning MC, the lack of practical micro/nanoscale MC devices and MC testbeds has led researchers to make overly simplifying assumptions about the implications of the channel conditions and the physical architectures of the practical transceivers in developing theoretical models and devising communication methods for MC. On the other hand, MC imposes unique challenges resulting from the highly complex, nonlinear, time-varying channel properties that cannot be always tackled by conventional information and communication tools and technologies (ICT). As a result, the reliability of the existing MC methods, which are mostly adopted from electromagnetic communications and not validated with practical testbeds, is highly questionable. As the first step to remove this discrepancy, in this study, we report on the fabrication of a nanoscale MC receiver based on graphene field-effect transistor biosensors. We perform its ICT characterisation in a custom-designed microfluidic MC system with the information encoded into the concentration of single-stranded DNA molecules. This experimental platform is the first practical implementation of a micro/nanoscale MC system with nanoscale MC receivers, and can serve as a testbed for developing realistic MC methods and IoNT applications.

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