Este artigo apresenta uma experiência de formação educacional e de assistência médica, utilizando a telemedicina como recurso tecnológico para a promoção e prevenção em saúde, além da capacitação profissional de populações ribeirinhas do baixo Madeira, no Estado de Rondônia. A atuação contou com a constituição de um pequeno pólo de telemedicina na comunidade de Santa Catarina, localizada no rio Madeira, há duzentos quilômetros do município de Porto Velho. A experiência no campo foi realizada entre 17 e 31 de julho de 2006, promovendo a inclusão de moradores de nove comunidades ribeirinhas. O sistema permitiu a troca simultânea de vídeo e áudio em tempo real, possibilitando acesso à informação, assistência médica e palestras sobre prevenção em saúde básica à população em geral. A realização deste projeto mostrou que a implantação da telemedicina é uma alternativa para a melhor distribuição dos serviços de saúde. Além de levar o atendimento a populações menos favorecidas, permite a reintegração social de pessoas preteridas pelo isolamento geográfico, auxilia na difusão de informação, proporciona capacitação aos moradores e futuros usuários do sistema, promove a prevenção em saúde, desenvolvendo a responsabilidade da população para uma melhor da qualidade de vida da região.

A specific, fast and sensitive LC-MS/MS assay was developed for the determination of bupropion and its metabolite hydroxybupropion in human plasma using lidocaine as the internal standard. The limit of quantification was 3.13 ng/ml for bupropion and 7.81 ng/ml for hydroxybupropion. The method was linear in the studied range of 3.13 -400.00 ng/ml for bupropion and 7.81 -1000 ng/ml for hydroxybupropion. This analytical method was applied to a comparative pharmacokinetic study, in which seventy eight volunteers (39 men and 39 female) aged between 18 and 50 years received a single oral dose of 150 mg of reference and test bupropion formulation, in an open, two-period, balanced randomized, crossover protocol. Group 1 received the medication without any additional meal. Group two received a hyperlipemic meal 30 min before the medication. Based on the 90% confidence interval of the individual ratios for C max and AUC 0-inf , it was concluded that the test formulation is bioequivalent to the reference formulation with respect to the rate and extent of absorption of both bupropion and hydroxybupropion and that food intake before the drug administration had no effect in the relative pharmacokinetic parameters. However, the hyperlipemic meal significantly increased the bupropion absorption.

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A rapid, sensitive, and specific method based on liquid chromatography= tandem mass spectrometry (LC-MS=MS) was developed and validated for the determination of propranolol in human plasma using metoprolol as internal standard. The drugs were extracted from plasma by liquid-liquid extraction and separated isocratically on a Phenomenex Synergi Fusion-RP C 18 analytical column, 4 mm (150 mm  4.6 mm i.d.) maintained at 30 C, with acetonitrile=water (95=5, v=v): 100 mM ammonium acetate: 100 mM acetic acid (65:15:20 v=v=v) as mobile phase, run at a flow rate of 1 mL min À1 (split 1:3). Detection was carried out by positive electrospray ionization (ESIþ) in selected reaction monitoring (SRM) mode. The chromatographic separation was obtained within 3.0 min and was linear in the concentration range of 2-150 ng mL À1 (r 2 ¼ 0.9969). The method was successfully applied for the bioequivalence study of two tablet Correspondence: Sérgio Luiz Dalmora, formulations (test and reference) of propranolol 80 mg after single oral dose administration to 36 healthy human volunteers, using an open, randomized, two period crossover design with one week wash out interval.The geometric means ratios of C max and AUC (0-1) were 99.77 and 103.70%, respectively, with both the confidence intervals between 90.12-112.92% demonstrating the bioequivalence of the two formulations.

Aos meus pais, irmãos e esposa Graziela de Oliveira Semenzati pela ajuda em todo o processo da vida.