The objective of this study is to assess the hydrothermal performance of a non-Newtonian hybrid nanofluid with temperature-dependent thermal conductivity and viscosity compared with a Newtonian hybrid nanofluid with constant thermophysical properties. A counter-current doublepipe mini-channel heat exchanger is studied to analyze the effects of hybrid nanofluid. The nanofluid is employed as the coolant in the tube side while the hot water flows in the annulus side.Two different nanoparticles including Tetra Methyl Ammonium Hydroxide (TMAH) coated Fe3O4 (magnetite) nanoparticles and Gum Arabic (GA) coated Carbon Nanotubes (CNTs) are used to prepare the water based hybrid nanofluid. The results demonstrated that the non-Newtonian hybrid nanofluid always has a higher heat transfer rate, overall heat transfer coefficient, effectiveness, and performance index than those of the Newtonian hybrid nanofluid, while the opposite is true for pressure drop and pumping power. Supposing that the Fe3O4-CNT/water hybrid nanofluid is a Newtonian fluid with constant thermal conductivity and viscosity, leads to a large error in the
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