The present work studied the effect of some natural substances (Egyptian and Chinese propolis ethanolic extractcinnamon-clove-peppermint ethanolic extract) against the 4 th larval instar of G. mellonella. The experiments in this study were conducted in the experimental laboratory of Biology Department, Faculty of Science, Taibah University. Potential activities of active materials on mortality percent and duration of greater wax moth at four concentrations (0.5, 1.0, 2.0 and 4.0 % w/w) were studied, and it is obvious that the mortality effect depend on the kind of materials and concentration. Peppermint ethanolic extract recorded (53.33±1.86%) larvae mortality compare to other materials and control, on other hand the Egyptian propolis ethanolic extract and clove had no effect on great wax moth at 0.5%. the pupa mortality increased in concentration 4% in Egyptian and Chinese propolis ethanolic extract, cinnamon, clove and peppermint ethanolic extract (26.66±0.00, 23.33±1.00, 43.33±4.00, 33.33±2.00 and 8.33±10.01%, respectively). The adult stage was the more resistance stage. In the larval duration, the highest effect were recorded in peppermint ethanolic extract which recorded 26.67± 3.48 at 4% concentration with 31.62 % reduction of normal (control) duration and followed by Chinas propolis and cinnamon (30.33±1.33 and 30.08±0.08 day, respectively) with 22.23 and 22.87 % reduction respectively at 4%concentration.