Background: Diabetic Peripheral Neuropathy (DPN) is an important micro-vascular complication of Diabetes Mellitus (DM), considered as a major contributor to foot ulceration and lower limb amputation among diabetic patients and have remarkable negative effect on patient's quality of life. Aim of Study:This study aimed to estimate the prevalence and possible risk factors of DPN among patients attending diabetic center in Aden governorate, Yemen. Patients and Methods:This cross-sectional retrospective study review prevalence of peripheral neuropathy among patients aged 18-70 years with type 1 and 2 DM (T1D, T2D), were 124 patients assessed by neurosymptoms and neurodisability scores (NSS and NDS respectively). Descriptive statistic and logistic regression analysis were done. Results:The prevalence of DPN based on NSS and NDS was 60.48%. Risk factors significantly associated with DPN were age (p 0.015), educational level (p 0.013), type 2 diabetes (p 0.022), and duration of diabetes (p 0.001), dyslipidemia (p 0.009), abdominal obesity (p 0.001), body mass index (p 0.036) and retinopathy (p 0.035). Female gender, hypertension, elevated glycated hemoglobin and the presence of albuminuria were associated with higher frequency of DPN although this relation was statistically non-significant. Logistic regression analysis revealed that Illiteracy (OR 8.75,), dyslipidemia (OR 1.97, 95% CI 1.04-24.44), long standing of diabetes (OR 1.14, 95% CI 1.05-1.23), and abdominal obesity (OR 1.05, 95% CI 1.01-1.09) were significantlly associated with DPN.Conclusions: A higher prevalence was observed with illiteracy, dyslipidemia, longer duration of diabetes and abdominal obesity.

Rheumatoid arthritis (RA) is a chronic autoimmune disease with multiple morbidity burdens. Early diagnosis of RA is the main key in management and prevention of disease complications. Much research nowadays is looking for a serological marker with high accuracy in diagnosis of early RA cases. Our aim in this study was to evaluate the role of anti-mutated citrullinated vimentin (anti-MCV) antibodies in the early diagnosis of RA. In addition to compare its diagnostic sensitivity and specificity with anti-cyclic citrullinated peptide antibodies (anti-CCP) and RF antibodies in early versus established RA patients. This prospective cross-sectional study included 80 participants: 40 RA patients (20 early RA patients and 20 established RA patients), 20 patients with other rheumatic diseases (as a disease control group), and 20 apparently healthy participants as normal controls. All participants underwent history taking, clinical examination (general, articular assessment and calculation of disease activity score (DAS28-ESR)) for RA patients, radiological and laboratory investigations (RF, anti-CCP2 and anti-MCV antibodies measurements by ELISA technique). The results showed that the mean values of anti-CCP2 and anti-MCV were significantly increased in RA cases compared to the control groups (p=0.00 and p=0.01, respectively). Anti-MCV had sensitivity and specificity of 63% and 83%, respectively for diagnosing of early RA at area under curve of 0.80 compared to sensitivity and specificity 37% and 100%, respectively for anti-CCP2. Also, both (anti-CCP2 and anti-MCV) had positive significant correlations with ESR (p<0.001 and p=0.02, respectively), CRP (p=0.01 and p=0.02, respectively) and DAS 28 (p<0.001 for both). In conclusion, our data indicated that anti-MCV antibodies may represent a valuable marker for diagnosis of early RA cases.