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This research aims to assess environment, health and safety condition in Integrated Solid Waste Treatment Zone in North-west of Ho Chi Minh City, assess its current management system, establish an Environment-health-safety management system, develop a strategic management program and supporting programs for EHSMS implementation. This research found that environmental problems in STZ are leachate, gas from landfill without a treatment system, environmental accidents and harmful insects. Most popular diseases types in STZ staffs are ear-nose-throat disease (43% in 2005 and 58% in 2000), and eye disease (28% in 2005 and 26% in 2006). Research proposes environment-health-safety management programs available for STZ including supply of personal protective equipments, development of guidelines, capacity building, and health care.