Gadoxetate-enhanced liver MRI results in early enhancement of normal parenchyma in patients The start of the hepatobiliary phase coincides with the late arterial phase. This may confound the assessment of lesion appearance compared to extracellular contrast. Different parenchymal enhancement patterns after gadoxetate were found for normal parenchyma.

Purpose To investigate the feasibility of selective arterial and portal venous liver perfusion imaging with spin labelling (SL) MRI, allowing separate labelling of each blood supply. Methods The portal venous perfusion was assessed with a pulsed EPISTAR technique and the arterial perfusion with a pseudo-continuous sequence. To explore precision and reproducibility, portal venous and arterial perfusion were separately quantified in 12 healthy volunteers pre-and postprandially (before and after meal intake). In a subgroup of 6 volunteers, the accuracy of the absolute portal perfusion and its relative postprandial change were compared with MRI flow measurements of the portal vein. Results The portal venous perfusion significantly increased from 63±22 ml/100g/min preprandially to 132±42 ml/100g/ min postprandially. The arterial perfusion was lower with 35± 22 preprandially and 22±30 ml/100g/min postprandially. The pre-and postprandial portal perfusion using SL correlated well with flow-based perfusion (r 2 =0.71). Moreover, postprandial perfusion change correlated well between SL-and