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Ten postmenopausal women received 8 consecutive (1 hour interval) i.v. bolus injections of either 25 or 500 micrograms of LH-RH. Gonadotropin release was monitored before and during LH-RH stimulation. After the first LH-RH bolus a dose-dependent LH release was seen. All consecutive LH-RH boli elicited similar LH responses resulting in pulse-type LH release. Throughout the whole stimulation period the pituitary gland remained highly responsive to LH-RH, FSH release was uncharacteristic. It is concluded that during postmenopause LH-RH is hyper-secreted. Thus the pituitary gland remains responsive to repeated injections of even supraphysiological LH-RH doses.

Twenty-two patients, average age 22 years, were treated for androgenization phenomena with a combination preparation containing ethinyl estradiol and chlormadinone acetate (Neo-Eunomin) over a period lasting 12 cycles. Under this therapy acne, seborrhea, alopecia and hirsutism improved. The hepatic metabolism parameters checked before and during the study (alkalic phosphatase, SGPT, gamma-GT and total bilirubin) showed no pathologic changes and decreased significantly toward the end of the treatment period. SGOT remained uninfluenced. The effects on the lipoproteins checked were favorable, as the atherogenic index (LDL/HDL) dropped from 2.2 prior to therapy to 1.7 in the twelfth cycle of the treatment period. The HDL fraction increased significantly in the very first cycle, while the LDL fraction remained almost constant. There was a significant increase in cholesterol and triglycerides. The serum androgen count (testosterone and DHEA-S) was significantly lowered. There was a clear decrease in testosterone in saliva.

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