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The implications of our findings are twofold. First, we demonstrate that it is possible to prevent enzymatic transformations by blocking the enzyme's access to its substrate using a synthetic small molecule to mask the substrate. Second, we show that it is feasible to derive molecules from combinatorial libraries that bind a specific epitope on a protein by selecting these molecules with the isolated peptide epitope.

Combinatorial libraries offer a new powerful tool for gathering empirical information about host/guest interactions and for developing catalysts for organic reactions. Combinatorial approaches to molecular recognition are discussed, i.e. torial approaches are also reviewed. screening of libraries of ligands with synthetic receptors and libraries of synthetic receptors with the ligands for which selective binding is desired. Recent achievements in the development of new catalysts for organic synthesis using combina-