Background:Amlapitta is a commonly encountered disease of Annavaha Srotasa (gastrointestinal system) described in various classical Ayurvedic texts. The cardinal features of Amlapitta are Avipaka (indigestion), Hritkantha Daha (heart and throat burn) and Tikta-Amlodgara (sour and bitter belching). This disease can be correlated with gastroesophageal reflux disease based on the clinical features. Baladi Manduram is one of the unique formulations mentioned in Rasa Kamadhenu indicated for the management of Amlapitta.Aims:This study is aimed to evaluate the efficacy of Baladi Manduram in the management of Amlapitta.Materials and Methods:A non-randomized, single-armed, open-labeled clinical trial was conducted in thirty patients having classical symptoms of Amlapitta, administered with 500 mg of Baladi Manduram twice a day after meals for 30 days. The assessment was done based on subjective parameters, i.e., Amlodgara (sour belching), Daha (heart burn), Gaurava (heaviness), Utklesha (nausea), Avipaka (indigestion) and Kshudha Alpata (loss of appetite). The results were statistically analyzed using the paired t-test.Results:Statistically highly significant relief (P < 0.001) was noted in Amlodgara, Hritkantha Daha, Utklesha and Agnimandya and statistically highly significant relief (P < 0.01) was seen in Gaurava and Avipaka.Conclusion:Baladi Manduram can be considered as an effective formulation in the management of Amlapitta.