Background: Preeclampsia (PE) is a leading cause of maternal morbidity and mortality worldwide. Early identification of PE in the first trimester helps the introduction of early preventative measures initiated before 16 weeks of gestation in patients at high risk of PE. Aim of the study: to evaluate the impact of self-care guidelines on women's awareness and identification of early signs and symptoms of pre-eclampsia. Subjects and Methods: Quasiexperimental research design was utilized in the current study. Setting: This study was conducted at outpatient clinics at Minia university hospital for Maternity and Child which serves pregnant woman in Minia city. Sample: A purposive sample of 100 pregnant women was divided equally and alternatively into two equal groups (n= 50) for a control group who received routine care and (n= 50) for study group who received self-care guideline. Tools: The current data was collected by using a tool composed of three parts: part I: semi-structured interviewing questionnaire. Part Two: Observation checklist adapted from research literature to assess pregnant women for presence of early signs and symptoms of preeclampsia. Part Three: standardized self-care guideline used for identification of early signs and symptoms of preeclampsia Results: The main findings of the study revealed that (44) 88% of control group has unsatisfactory level regarding knowledge score compared with (38)76% of the study group. Also, this study showed that that there was high statistical significant correlation between study group regarding level of severity and total knowledge score pretest and posttest with p-value (0.010, 0.000) study group who had a good knowledge score had low level of severity and low signs and symptoms detected. Conclusion: educational guidelines were effective in improving pregnant women knowledge regarding early detection of signs and symptoms and decreasing the maternal and neonatal mortality and morbidity rate. Recommendations: This study recommended that: there is a necessity to design continuous health education program to pregnant women and their families about preeclampsia, many seminars and awareness campaigns related to pre-eclampsia should be organized for developing preeclampsia knowledge and self-care measures for prevention and control of it.