Background Cat-scratch disease typically presents with various ocular manifestations such as uveitis, vitritis, retinitis, retinochoroiditis, and optic neuritis. However, fundus nodular lesions was rarely reported. In our study, we reported a case of Cat-Scratch disease with binocular fundus nodular lesions. Case presentation An 11-year old male presented with uveitis in the right eye and bilateral fundus nodular lesions after indirect contact with unvaccinated cats. Comprehensive ancillary examinations including wide-angle fundus photography, ultrasonography, fluorescein fundus angiography, optical coherence tomography, and orbital magnetic resonance imaging were performed to elucidate the multidimensional features of the binocular lesions. Metagenomics next-generation sequencing was utilized to confirm the diagnosis of Cat-scratch disease. The patient’s condition showed improvement after a 6-month combination treatment regimen involving systemic administration of doxycycline hyclate and methylprednisolone tablets, as well as local application of mydriatic and corticosteroid eye drops. Conclusions We firstly reported a case of Cat-scratch disease presenting simultaneously with uveitis and fundus nodular lesions caused by Bartonella henselae infection in a child. Timely diagnosis and treatment with antibiotics and corticosteroids showed promising outcomes for the prognosis of these ocular disorders.

Background Cat-scratch disease usually manifests with uveitis, vitritis, retinitis, retinochoroiditis and optic neuritis, yet, with fundus nodular lesions rarely reported. In our study, we report a case of Cat-Scratch disease with binocular fundus nodular lesions. Case presentation An 11-year old male presented with uveitis (right eye) and binocular fundus nodular lesions after indirect contact with unvaccinated cats. Ancillary examinations (Wide-angle fundus photography, Ultrasonography, Fluorescein fundus angiography, Optical coherence tomography and Orbital Magnetic Resonance Imaging) were conducted to describe the multidimensional features of the binocular lesions. Metagenomics next-generation sequencing confirmed the diagnosis of Cat-scratch disease. The patient’s condition improved after 6-month combination treatment of systemical doxycycline hyclat and methylprednisolone tablets plus local mydriatic and corticosteroid eye drops. Conclusions We firstly reported a case simultaneously combined with uveitis and binocular fundus nodular lesions secondary to infection of Bartonella henselae in a child. Timely diagnosis and treatment with antibiotics and corticosteroids could improve the prognosis of these disorders.

With hollow mesoporous silica (hMSN) and injectable macroporous hydrogel (Gel) used as the internal and external drug-loading material respectively, a sequential drug delivery system DOX-CA4P@Gel was constructed, in which combretastatin A4 phosphate (CA4P) and doxorubicin (DOX) were both loaded. The anti-angiogenic drug, CA4P was initially released due to the degradation of Gel, followed by the anti-cell proliferative drug, DOX, released from hMSN in tumor microenvironment. Results showed that CA4P was mainly released at the early stage. At 48 h, CA4P release reached 71.08%, while DOX was only 14.39%. At 144 h, CA4P was 78.20%, while DOX release significantly increased to 61.60%, showing an obvious sequential release behavior. Photodynamic properties of porphyrin endow hydrogel (φΔ(Gel)=0.91) with enhanced tumor therapy effect. In vitro and in vivo experiments showed that dual drugs treated groups have better tumor inhibition than solo drug under near infrared laser irradiation, indicating the effectivity of combined photodynamic-chemotherapy.