Cat-scratch disease manifesting as uveitis and binocular fundus nodular lesions: a case report

Hong, Hao; Li, Tianxi; Ye, Ying; An, Q.; Liu, Hu; Liang, Kang

doi:10.1186/s12886-023-03063-4

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Patients with hypo-immunity, on the other hand, exhibit atypical CSD caused by infection of organs and tissues ( Juan and Gan, 2011 ) outside the lymph nodes through the lymphatic or bloodstream flow ( Florin et al., 2008 ). CSD, in this case, may result in ocular ( Johnson, 2020 ; Tey et al., 2020 ; Hong et al., 2023 ), neurologic ( Florin et al., 2008 ; Juan and Gan, 2011 ), musculoskeletal ( Maman et al., 2007 ; Dornbos et al., 2016 ), skin ( Florin et al., 2008 ), and breast involvement ( Gamblin et al., 2005 ) as well as other manifestation and syndromes (e.g., pneumonitis, pleural effusion, idiopathic thrombocytopenic purpura, anaphylactoid purpura, erythema multiforme, hypercalcemia, glomerulonephritis, and myocarditis).…”

Section: Introductionmentioning

confidence: 99%

A case report of diagnosis of cat-scratch disease using metagenomic next-generation sequencing

Zhou,

Zheng,

Zhang

et al. 2024

Front. Cell. Infect. Microbiol.

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Cat-scratch disease (CSD) is an anthropozoonotic infection caused by Bartonella henselae, and it is one of the most common causes of lymph node infections in children and adolescents. B. henselae, belonging to the genus Bartonella, is a common human pathogen of human beings. CSD commonly develops as a result of cat scratches and bites or when injured skin comes into contact with cat saliva. The manifestation of CSD clinically differs for each patient based on their immune system. Individuals who have healthy immune systems generally manifest minimal clinical symptoms and do not necessitate any form of treatment. However, patients who have hypo-immunity require prompt medical attention due to the potential manifestation of severe symptoms that affect multiple systems of the body. Long latency and atypical clinical manifestations are characteristics of CSD. Bartonella isolation and identification are challenging procedures that require specialized equipment. There is no gold standard method for CSD diagnosis, and misdiagnosis and missed diagnosis rates are typically high. We present the case of a middle-aged male patient who developed fever, chills, anal distension, dizziness, and muscle pain for 10 days. The patient had a documented history of cat bites 1 month prior to the onset of symptoms. Following admission, he underwent an examination to determine superficial lymphadenopathy and hypoimmunity. Additionally, he had a fever during the disease. As the patient refused a needle biopsy of lymph nodes, metagenomic next-generation sequencing (mNGS) was employed and B. henselae was detected in the peripheral blood. The patient was diagnosed with CSD and treated with a combination of azithromycin and doxycycline. The fever symptoms were alleviated, and the patient was ultimately discharged. As a result of this case, we suggest that mNGS be used as a crucial supplementary diagnostic tool for individuals with compromised immune systems who may have CSD, especially when conventional diagnostic methods are inconclusive.

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Section: Introductionmentioning

confidence: 99%

A case report of diagnosis of cat-scratch disease using metagenomic next-generation sequencing

Zhou,

Zheng,

Zhang

et al. 2024

Front. Cell. Infect. Microbiol.

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Neuroretinitis due to cat scratch disease: The value of postcontrast FLAIR

Motta,

Oliveira,

de Mendonça Cardoso

et al. 2024

Journal of Clinical Neuroscience

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Unilateral Exudative Retinal Detachment and Uveitis Accompanied by a Large Subretinal Deposit on the Macula Secondary to Bartonella Henselae Infection

Liang,

Cui,

et al. 2024

Diagnostics

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Bartonella henselae is a Gram-negative bacillus, mainly parasitizing on cats. When a child is scratched by a cat, they may present with the disease symptoms including regional lymphadenopathy, malaise, fever, and splenomegaly, which is known as cat-scratch disease (CSD). Ocular manifestations occur in 5–10% of patients with CSD. Neuroretinitis is the most common, and, in addition, Parinaud oculoglandular syndrome, endophthalmitis, retinochoroiditis, vascular occlusions, multiple mass-like lesions resembling ocular metastases, serous macular detachments, and retinal vasoproliferative lesions may also occur. We report a case of unilateral exudative retinal detachment and uveitis with a large subretinal deposit on the macula in a 6-year-old female with CSD, along with lymphadenitis on her left thigh. To the best of our knowledge, this case of exudative retinal detachment and uveitis with a large subretinal deposit under the retina affecting the macular area above the optic disc has not been previously reported.

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Cat-scratch disease manifesting as uveitis and binocular fundus nodular lesions: a case report

Cited by 4 publications

References 14 publications

A case report of diagnosis of cat-scratch disease using metagenomic next-generation sequencing

A case report of diagnosis of cat-scratch disease using metagenomic next-generation sequencing

Neuroretinitis due to cat scratch disease: The value of postcontrast FLAIR

Unilateral Exudative Retinal Detachment and Uveitis Accompanied by a Large Subretinal Deposit on the Macula Secondary to Bartonella Henselae Infection

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