<p class="Abstract">The alveolar cleft is known as the developmental defect of bone in alveolar process of maxillae which occurs in 75% of the cleft lip and palate patients with different types of clinical presentation like unilateral or bilateral and complete or incomplete. Secondary alveolar cleft reconstruction with autogenic spongy bone grafting (osteoplasty) at the stage of mixed dentition is commonly accepted treatment to help in the maintenance of maxillary arch continuity, repairing of oronasal fistula, eruption of the permanent dentition, enhancement of nasal symmetry through providing alar base support and improving speech. As of late, conflicting argument of alveolar cleft management is continuing regarding treatment planning with timing, graft materials, surgical techniques as well as methods of evaluation of the progress of alveolar osteoplasty. Now-a-days, experiments have made for the application of allogeneic bone, artificial bone, and recombinant human bone morphogenetic protein (rhBMP), along with growth factors to diminish the donor-site morbidity associated autogenic bone grafting. The purpose of this review is to discuss about pathogenesis and aetiology of cleft defects, surgical techniques, assessment of progress of alveolar bone graft and proposed future materials for bone graft.</p>

<p class="Abstract">Oral cancer is becoming frightful public health issue because of its raising incidence as well as mortality rates worldwide. Out of all types of oral cancer, the oral squamous cell carcinoma is the most common malignant tumor with an incidence of about 90%. This fatal disease is diagnosed through a comprehensive clinical examination followed by the histological assessments forming the diagnostic gold standard. Although the oral cavity is simply accessible, but maximum oral cancers are usually diagnosed at the late stage. Consequently, it is necessary to implicate newer screening and early diagnosing approaches which will diminish the morbidity as well as mortality related to this disease. Saliva which is a complex biological fluid has a direct relation with the oral cancer lesion and contains abnormal DNA, RNA, protein molecules released by the malignant cells. These can be labelled as neoplastic biomarkers proposed to play an important role in diagnostic, therapeutic and prognostic purposes for oral cancers as well as other diseases. The aim of this review paper is to concisely discuss the different types of potential salivary biomarkers as well as their interaction for screening of oral cancers.</p>

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