ABSTRAK Merkaptopurin merupakan obat kemoterapi yang digunakan pada fase konsolidasi dan pemeliharaan pada pasien pediatri kanker leukimia limfoblastik akut (LLA). Merkaptopurin diduga memiliki hubungan erat dengan terjadinya toksisitas pada hepatologi. Penelitian ini bertujuan untuk mengetahui angka kejadian, derajat keparahan dan penatalaksanaan toksisitas serta faktor risiko yang mempengaruhi terjadinya toksisitas hepatologi penggunaan 6-MP dalam fase pemeliharaan pada pasien pediatri kanker leukimia limfoblastik akut di RS Kanker Dharmais Jakarta. Penelitian ini dilakukan dengan desain observasional cross sectional dengan mengambil data pasien secara retrokspetif dan prospektif selama periode Maret–April 2014. Subyek penelitian adalah pasien kanker LLA anak yang berobat di RS Kanker Dharmais Jakarta dari tahun 2013 sampai dengan periode Maret-April 2014 yang sedang dalam fase pemeliharaan. Subyek yang memenuhi kriteria inklusi adalah 23 pasien LLA yang mendapatkan 6-MP pada fase pemeliharaan. Pengumpulan data dilakukan dengan melihat rekam medik untuk mendapatkan data identitas pasien dan data hepatologi. Hasil penelitian menunjukkan bahwa angka kejadian toksisitas hepatologi paling banyak terjadi pada peningkatan SGPT sebesar 13,05%. Derajat keparahan pada toksisitas hepatologi paling banyak terjadi pada derajat 2 (8,70% dan 13,04%). Berdasarkan faktor-faktor yang mempengaruhi terjadinya toksisitas hepatologi, tidak terdapat perbedaan yang signifikan pada hasil penelitian. Kata kunci : 6-merkaptopurin, toksisitas, hepatologi, leukimia limfoblastik akut ABSTRACT Mercaptopurine is a chemotherapy drug that used in the consolidation and maintenance phase in pediatric patients with acute lymphoblastic leukemia (ALL). Mercaptopurine is supposed to have relationship with the occurrence of toxicity in hepatology. This study was aimed to determine the patient incidence, severity and management of toxicity and risk factors that affect the occurrence of hepatologic toxicity using of 6 - MP in the maintenance phase in pediatric patients with acute lymphoblastic leukemia in Dharmais Cancer Hospital Jakarta. This research was carried out by cross-sectional observational design with data was taken retrospectively and prospectively during the period from March to April 2014. The study subjects were patient who have been getting treatment of maintenace phase in Dharmais Cancer Hospital Jakarta from 2013 until March-April 2014. The Subjects who met the inclusion criteria were 23 patients of ALL received 6 - MP in the maintenance phase. Data was collected by looking at the medical records for getting of the patient's identity and data hepatology. The results showed that there the incidence of the increased of SGPT was the most prevalent (13, 05 %) . The severity of the most common hepatologic toxicity was at level 2 (8,70% and 13,04%). Based on the influence of the hepatology toxicity factors, there were not different significant of the result of research. Keywords : 6-mercaptopurine, toxicity, hepatology, acute lymphoblastic leukemia

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Mercaptopurine is a chemotherapy drug that used in the consolidation and maintenance phase in pediatric patients with acute lymphoblastic leukemia ( ALL). Mercaptopurine is supposed to have relationship with the occurrence of toxicity in hepatology. This study was aimed to determine the patient incidence , severity and management of toxicity and risk factors that affect the occurrence of hepatologic toxicity using of 6 - MP in the maintenance phase in pediatric patients with acute lymphoblastic leukemia in Dharmais Cancer Hospital Jakarta. This research was carried out by cross-sectional observational design with data was taken retrospectively and prospectively during the period from March to April 2014. The study subjects were patient who have been getting treatment of maintenace phase in Dharmais Cancer Hospital Jakarta from 2013 until March-April 2014. The Subjects who met the inclusion criteria were 23 patients of ALL received 6 - MP in the maintenance phase. Data was collected by looking at the medical records for getting of the patient's identity and data hepatology. The result showed that there was a correlation between patient characterision on hepatology toxicity, on SGOT age and weight with SGPT both of them has significant value, it was 0,036 (P<0,05)

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