Background: Mucormycosis is a rare, opportunistic fungal infection with high morbidity and mortality. Coronavirus disease 2019 (COVID-19) associated mucormycosis has been increasing in frequency since early 2021, particularly among patients with uncontrolled diabetes and systemic corticosteroid treatment. Aims and Objectives: The aim of the study was to study mucormycosis occurrence in COVID-19 patients at Government General Hospital, Nizamabad – A tertiary care center and to correlate mucormycosis with comorbidities and previous treatment modalities among admitted post COVID-19 patients. Materials and Methods: Cross-sectional retrospective study was done for 3 months, from June 2021 to August 2021. Fifty suspected cases of mucormycosis specimens sent to the Department of Pathology, Government General Hospital, Nizamabad for histopathological diagnosis were considered. Clinical history and treatment details were noted. Tissues obtained were fixed in 10% formalin, routine hematoxylin and eosin (H&E) stains were done. Gomori’s methenamine silver stains were done. Results: Mucormycosis was most common in males 37 (74%) and common in the age group of 41–50 years (26%). Diabetes mellitus is the most common comorbidity (60%). The mean duration between diagnosis of COVID-19 and development of symptoms of mucor was 6–40 days. Out of 50 cases, 46 patients received steroid therapy and 39 cases were given oxygen support. Conclusion: Mucormycosis is a rapidly progressive life-threatening opportunistic infection. Post COVID-19 patients with uncontrolled diabetes are more prone to it and an important predisposing factor. Treatment with steroid therapy and oxygen support must be carefully monitored and used in a vigilant manner. Histopathological examination and clinical correlation are essential for early diagnosis and treatment.
Background: A ventilated middle ear space is an essential component of a functioning middle ear transformer mechanism. A mastoid ventilation tube (MVT) placed post-aurally in the antrum near the aditus is used in this study for the benefit of improvement in results of tympanoplasty. In support of this concept, very few experimental documents are reported. Aims and Objectives: The aims of this study were to find out if the MVT has any effect on the outcome of tympanoplasty in cases of chronic suppurative otitis media (CSOM) tubo-tympanic disease. Materials and Methods: This study was performed in 50 cases which were selected from the total number of cases using stratified random sampling method. In the research, patients with CSOM, who did not respond to medical therapy and required a combined approach tympanoplasty, were enrolled. Patients who needed just myringoplasty and those found to have cholesteatoma intraoperatively were not included in the research. Results: The study showed significant improvement in graft uptake, air-bone closure, and hearing in cases with MVT, thus resulting in better success rate in cases with MVT than cases without MVT. Furthermore, most of the cases had sclerosed mastoids and very few cases had complications such as MVT block and post-operative discharge. Conclusion: The MVT had a beneficial effect on the final outcome of combined approach tympanoplasty in cases of CSOM tubo-tympanic type active stage.
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