No abstract

No abstract

Background: Mosquito-borne diseases are among the common problems in developing countries. For centuries, herbal formulations have been used by tribal communities as medicines.A survey was carried out to document the insecticidal plants from fringe villages of Manas National Park. Materials and Methods: The survey was carried out from April to July 2020. The survey was conducted in a face-to-face manner with a ready-made questionnaire. Results: A total of 25 fringe villages were surveyed, and 57 informants were interviewed. Most of the informants were male (87%) and aged (>50 years old). A total of 24 plant species belonging to 18 families were recorded in the present study. Among the plant families, Solanaceae and Lamiaceae were the most famous families. Brassica rapa was the most popular plant with five citations, followed by Cinnamomum tamala and Nicotiana tabacum. Leaves were the most commonly used plant parts, followed by stems. The survey also reported that smokes, produced by burning plant parts, are the most commonly practised mode of use, followed by the rubbing of raw juices of plant parts to repel mosquitoes by fringe villagers of Manas National Park. Conclusion: With a solid ethnobotanical knowledge system supported by scientific evidence, the present study may be used by researchers to explore further the insecticidal and mosquitocidal activities of the plants.

Persicaria strigosa is an important medicinal plant having several ethnomedicinal values. This study investigated the phytochemical contents, antiproliferative, and apoptosis-inducing properties of P. strigosa. The phytocompounds were identified by the Gas Chromatography Mass Spectrometry (GC-MS) technique. Antiproliferative and apoptosisinducing properties were conducted in Dalton's lymphoma cells. In-silico molecular docking, drug-likeness, and absorption, distribution, metabolism, excretion, and toxicity (ADMET) were carried out to study the binding affinity and drug-likeness of the compounds. The study revealed a dose-dependent antiproliferative activity of the plant. GC-MS study identified 12 compounds from the ethyl acetate extract. Phytompounds C2, C5, C6, C7, and C12 showed the best binding affinity with the anti-apoptotic proteins. The phytocompounds were predicted to possess drug-likeness properties and a good ADMET profile. The findings suggest that P. strigosa could be a potential source of anticancer agents.

Persicaria strigosa is an important medicinal plant having several ethnomedicinal values. The present study investigates the phytochemical contents, antiproliferative, and apoptosis-inducing properties of P. strigosa. The phytocompounds were identified by the GC-MS technique. Antiproliferative and apoptosis-inducing properties were conducted in DL cells. In-silico molecular docking, drug-likeness, and ADMET was carried out to study the binding affinity and drug-likeness of the compounds. The study revealed a dose-dependent antiproliferative activity of P. strigosa. Ethyl acetate extract showed the strongest activity compared to other extracts. Plant extract-treated cells showed morphological features of apoptotic cells. GC-MS analysis identified 12 compounds from the ethyl acetate extract. Compound C2, C5, C6, C7, and C12 showed the best binding affinity with the anti-apoptotic proteins. The phytocompounds were predicted to possess drug-likeness property and a good ADMET profile. The findings, thus, suggest that the Persicaria strigosa extract could be a potential source of anticancer agents.