Goitre is a thyroid gland enlargement due to the increase of thyroid tissue. Goitre can be classified from several aspects: physiological (euthyroidsm, hypothyroidsm, and hyperthyroidism), morphological (diffuse and nodular goitre), and clinical (toxic and non toxic goitre) aspects. Patients with euthyroid goitre have no symptoms because there is no abnormality with the thyroid function. This study aimed to obtain the profile of the non toxic multinodosa goitre patients with euthyroidism in Surgery Department Prof. Dr. R. D. Kandou Hospital Manado period from July 2012 to July 2014. This was a descriptive retrospective study using the medical record of the Surgery Department Prof. Dr. R. D. Kandou Hospital Manado. Of 25 non toxic goitre multinodosa patients, there were 21 (84%) female patient and 4 (16%) male patient. Patients with euthyroidism were 21 cases (84%) and with hypothyroidism 4 cases (16%). Therapy of euthyroid goitre was surgery. The types of surgery for this 25 patient were as follows: 14 (56%) total thyroidectomy, 9 (36%) isthmolobectomy, 1 (4%) nearly total thyroidectomy, and 1 case (4%) subtotal thyroidectomy. Patients with enlargements in the neck should be checked for their thyroid glands and hormones even if they do not have any symptoms, especially if they come from iodine deficiency endemic area.Keywords: goitre, euthyroidAbstrak: Struma adalah pembesaran kelenjar tiroid karena terjadi penambahan jaringan kelenjar tiroid. Struma dapat diklasifikasikan berdasarkan fisiologis (eutirodisme, hipotiroidisme, dan hipertiroidisme), morfologi (struma difus dan nodular) serta berdasarkan klinis (struma toksik dan non toksik). Penderita struma yang eutiroid tidak mempunyai keluhan karena tidak terdapat gangguan fungsi tiroid. Penelitian ini bertujuan untuk mengetahui gambaran pasien struma multinodusa non-toksik yag eutiroid di Bagian Bedah RSUP Prof. Dr. R. D. Kandou Manado periode Juli 2012 – Juli 2014. Penelitian ini bersifat deskriptif retrospektif dengan memanfaatkan catatan medik di Bagian Bedah RSUP Prof. Dr. R. D. Kandou Manado. Dari 25 pasien struma multinodusa non-toksik ditemukan bahwa jenis kelamin perempuan sebanyak 21 pasien (84%) dan jenis kelamin laki-laki 4 pasien (16%). Jumlah pasien yang eutiroid sebanyak 21 kasus (84%) dan hipotiroid 4 kasus (16%). Terapi struma eutiroid ialah pembedahan. Dari 25 kasus struma multinodusa non-toksik didapatkan 14 kasus (56%) tiroidektomi total, 9 kasus (36%) istmolobektomi, 1 kasus (4%) tiroidektomi hampir total, dan 1 kasus (4%) tiroidektomi subtotal. Pasien dengan pembesaran di daerah leher sebaiknya langsung dilakukan pemeriksaan kelenjar dan hormon tiroid walaupun tanpa gejala apapun, terutama yang berasal dari daerah endemis kekurangan yodium.Kata kunci: struma, eutiroid

Introduction Hyperbaric oxygen therapy (HBOT), a procedure that involves the patient inhaling 100% oxygen gas under pressure, is currently used as an adjunctive treatment option for certain inflammatory conditions. HBOT can improve wound healing by increasing the rate of angiogenesis in injured tissue by increasing levels of vascular endothelial growth factor (VEGF). VEGF causes re-epithelialization, the migration of endothelial cells, and the formation of granulation tissue, which are involved in the wound healing process. Methods This study contains secondary data analyses of information previously collected in two separate studies, each concerning the effects of HBOT on diabetic foot ulcers and crush injury fractures at Prof. Dr. R. D. Kandou Hospital Manado and Siloam Hospital Manado from 2019 to early 2020. Results Based on the classification tree analysis, the predictors of HBOT success were leukocytes level (34%), platelet count (32%), and age (26%). The conditional inference tree analysis also indicated significant leukocyte levels, age, and platelet counts (p < 0.001), with which the interpretation of these results was the same as the classification tree analysis method. The results obtained from the random forest analysis revealed that the mean value of Gini reduction for leukocytes (207.3), platelets (110.2), age (97.9), and hemoglobin (57.9) can be used as indicators of successful HBOT. These three methods support that age, leukocytes, and platelets are determinants of HBOT success, while hemoglobin levels were only significant in one analysis method. Therefore, a new, proposed algorithm containing these factors was assembled from the results of this study. Conclusion HBOT cannot be separated from specific variables that contribute to and can predict its success.

This study aimed to analyze the relationship between gallstone and histopathological changes of gallbladder mucosa among patients with gallstones. Samples consisted of 38 patients with gallstones who were performed elective cholecystectomy either by laparoscopy or by laparotomy on them. Gallstones were analyzed macroscopically to determine the types of stones. Specimens of resected gallbladders were examined histopathologically to obtain the changes of gallbladder mucosa. The results showed that macroscopical analysis resulted in three types of gallstones: cholesterol stone (76.3%), pigmented stone (21.1%), and mixed stone 2.6%). Histopathologically, all resected speciments showed changes of gallbladder mucosa in the forms of chronic inflammation or associated with hyperplasia. There was no incidental cases of gallbladder cancer. An analysis of the relationship between the types of stones and the histopathological changes of gallbladder mucosa with the chi-square test showed an X2 value of 0.483 and a P value of 0.392. Conclusion: In this study, there was no relationship between the types of gallstones and the histopathological changes of gallbladder mucosa among patients with gallstone.Keywords: gallstone, cholecystectomy, gallbladder mucosaAbstrak: Penelitian ini bertujuan untuk menganalisis hubungan batu kandung empedu dengan perubahan mukosa kandung empedu pada pasien dengan batu kandung empedu. Sampel terdiri dari 38 pasien batu kandung empedu yang menjalani operasi elektif kolesistektomi, baik secara laparoskopik maupun secara terbuka. Batu kandung empedu dianalisis secara makroskopik untuk menentukan jenis batu. Spesimen reseksi kandung empedu diperiksa secara histopatologik untuk melihat ada tidaknya perubahan mukosa kandung empedu. Dari hasil analisis batu secara makroskopik didapatkan 3 jenis batu kandung empedu, yaitu batu kolesterol (76,3%), batu pigmen (21,1%), dan batu campuran (2,6%). Semua spesimen reseksi kandung empedu diperiksa secara histopatologik dan menunjukkan perubahan mukosa kandung empedu berupa radang kronis dan hiperplasia. Tidak terdapat penemuan secara insidental terhadap kanker kandung empedu. Analisis hubungan antara jenis batu kandung empedu dan perubahan mukosa kandung empedu dengan uji chi-square mendapatkan X2 = 0,483 dengan P = 0,392. Simpulan: Dalam penelitian ini tidak didapatkan hubungan antara jenis batu dan perubahan mukosa kandung empedu pada pasien dengan batu kandung empedu.Kata kunci: batu kandung empedu, kolesistektomi, mukosa kandung empedu

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The etiology of hypospadias is not certainly known and is still controversial. Environmental factors and their influence during pregnancy can be risk factors for increased incidence of hypospadias. This study was aimed to obtain the risk factors of hypospadias. This was a literature review study using three databases, as follows: ClinicalKey, PubMed, and Google Scholar. There were 47 literatures in this study. The results showed that from the 47 literatures containing risk factors of hypospadias, 8 literatures reported the relationship between pesticides and hypospadias; 3 literatures reported the relationship between smoking and increased risk of hypospadias; 6 literatures revealed that there was a strong relationship between maternal age and increased risk of hypospadias; 8 literatures showed that low births weight babies were associated with hypospadias and placental insufficiency as its cause; 5 literatures stated that several drugs consumed by pregnant women during the first trimester were related to the increased risk of hypospadias. In conclusion, environmental factors and contributors during pregnancy are the risk factors of hypospadias.Keywords: hypospadias, risk factors, environmental factors, contributors during pregnancy Abstrtrak: Etiologi hipospadia belum diketahui dengan pasti dan masih bersifat kontroversial. Faktor lingkungan serta hal yang berpengaruh selama kehamilan dapat menjadi faktor risiko peningkatan kejadian hipospadia. Penelitian ini bertujuan untuk mengetahui faktor risiko hipospadia. Jenis penelitian ialah literature review dengan menggunakan database ClinicalKey, PubMed, dan Google Scholar. Hasil penelitian mendapatkan bahwa dari 47 literatur yang memuat tentang faktor risiko hipospadia, 8 literatur memuat adanya hubungan antara pestisida dengan hipospadia, 3 literatur memuat bahwa merokok berkaitan dengan peningkatan risiko hipospadia, 6 literatur memuat bahwa usia ibu memiliki hubungan kuat dengan peningkatan risiko hipospadia, 8 literatur memuat bahwa bayi berat lahir rendah berkaitan dengan hipospadia dan insufisiensi plasenta menjadi penyebab terjadinya hal tersebut, 5 literatur memuat bahwa beberapa obat obatan yang dikonsumsi ibu hamil selama trimester pertama berkaitan dengan peningkatan risiko hipospadia. Simpulan penelitian ini ialah faktor lingkungan dan kontributor selama kehamilan merupakan faktor risiko hipospadia.Kata kunci: hipospadia, faktor risiko, factor lingkungan, Kontributor selama kehamilan