Background: Unicystic ameloblastoma is one of the different clinical variants of ameloblastoma which is less aggressive in its biological behavior. Aim: The present study was undertaken to retrospectively compare the clinical, radiologic, and histopathologic features of 50 cases of unicystic ameloblastoma in Indians. Methods: Biopsy records of 50 histologically diagnosed cases of unicystic ameloblastoma over 9-year (2010-2019) period were retrieved and analyzed for age, sex, site distribution, clinical presentation, radiologic features, and histopathology. Results: It was revealed that out of 50 cases, a male preponderance was seen. Age predisposition was seen to favor the 2 nd to 3rd decade, the most common site was the posterior aspect of lower jaw. Common histological type noted was luminal and intramural type (1.3). Conclusion: The study provides baseline data regarding the viable record for the distribution of odontogenic lesions in the sample population.

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