Hydroxyapatite (HA) is one of bioceramics which used in many biomedic applications. However, HA has poor mechanical properties. HA has be composited with material which has a good mechanical properties, such as nanosilica. In this study, synthesis HA was prepared by co-precipitation method. Base material to synthesis HA is onyx rock from Bojonegoro which contain 94.33 % Ca. While phosphate obtainable from Ammonium Dihydrogen Phosphate. The vickers hardness result using micro hardness vikers show that adding nanosilica is influence the mechanical properties of HA. The value of vikers hardness at adding nanosilica 10, 20, 30% respectively are 38.2; 42.3; 43.1 HVN while the porosity are 44.4; 40.7; 39.3 %. Keywords: nanosilica, HA-SiO 2 nanocomposites , porosity, Vickers Hardness, coprecipitation method Abstrak Hidroksiapatit (HA) merupakan biokeramik yang digunakan dalam aplikasi biomedis. Namun, HA memiliki sifat mekanik yang rapuh sehingga HA dikompositkan dengan material yang memiliki sifat mekanik baik yaitu nanosilika. Pada penelitian ini, sintesis HA dilakukan dengan menggunakan metode kopresipitasi. Bahan dasar pembuatan HA adalah batuan onyx Bojonegoro yang dijadikan sebagai sumber Ca dengan kemurnian 94,33% sedangkan sumber fosfat diperoleh dari Ammonium Dihidrogen Fosfat. Hasil uji kekerasan menggunakan microhardness vikers menunjukkan adanya pengaruh penambahan nanosilika pada kekerasan nanokomposit HA-SiO 2. Besarnya nilai kekerasan untuk masing-masing kadar nanosilika 10, 20, 30% berturut-turut adalah 38,2; 42,3; 43.1 HVN sedangkan nilai porositasnya adalah 44,4; 40,7; 39,3 %. Kata Kunci: nanosilika, nanokomposit hidroksiapatit-SiO 2 , porositas, kekerasan, metode kopresipitasi.

This study synthesized collagen-chitosan/PVA nanofiber composites using the electrospinning method. Characterizations included Fourier transform infrared spectroscopy (FTIR) and surface morphology using scanning electron microscopy (SEM). Investigations were carried out on tensile strength, degradation rate, and antibacterial test. It was found that the functional groups C–H, –OH, C–O, C–N, and N–H were suitable for PVA, collagen, and chitosan materials. The SEM showed that increasing the PVA composition caused a change in fiber diameter ranging from 34.64 to 71.63 nm. The tensile strength results show that the smallest nanofiber diameter has the highest ultimate strength value of 5.6 ± 0.4 MPa. In addition, it was found that the rate of degradation was in the range of 44%–76%. The antibacterial activity test was carried out using two types of bacteria, i.e., a gram-positive bacteria, S. aureus, and a gram-negative bacteria, E. coli. The test results showed that the collagen-chitosan/PVA nanofiber composite had a diameter of antibacterial inhibition for E. coli and S. aureus bacteria, respectively.

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