We report the results of an experimental and theoretical project dedicated to the study of Quasi Single Helicity Reversed Field Pinch plasmas. The project has involved several RFP devices and numerical codes. It appears that QSH spectra are a feature common to all the experiments.

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Non-thermal atmospheric gas plasma (AGP) exhibits cytotoxicity against malignant cells with minimal cytotoxicity toward normal cells. However, the mechanisms of its tumor-selective cytotoxicity remain unclear. Here we report that AGP-activated medium increases caspase-independent cell death and mitochondrial network collapse in a panel of human cancer cells, but not in non-transformed cells. AGP irradiation stimulated reactive oxygen species (ROS) generation in AGP-activated medium, and in turn the resulting stable ROS, most likely hydrogen peroxide (H2O2), activated intracellular ROS generation and mitochondrial ROS (mROS) accumulation. Culture in AGP-activated medium resulted in cell death and excessive mitochondrial fragmentation and clustering, and these responses were inhibited by ROS scavengers. AGP-activated medium also increased dynamin-related protein 1-dependent mitochondrial fission in a tumor-specific manner, and H2O2 administration showed similar effects. Moreover, the vulnerability of tumor cells to mitochondrial network collapse appeared to result from their higher sensitivity to mROS accumulation induced by AGP-activated medium or H2O2. The present findings expand our previous observations on death receptor-mediated tumor-selective cell killing and reinforce the importance of mitochondrial network remodeling as a powerful target for tumor-selective cancer treatment.

In this paper we present a statistical study of edge fluctuations taken with the Gas Puffing Imaging (GPI) diagnostics. We carry out a comparison of GPI signal from an extensive database including four devices (two Tokamaks and two Reversed Field Pinches). The data are analyzed in terms of their statistical moments Skewness and Kurtosis, as done in [B. Labit, et al, Phys. Rev. Lett. 98, 255002 (2007)]. The data align along parabolic curves, although different from machine to machine, with some spread around the best-fitting curve. A discussion about the meaning of the parabolic trend as well as the departure of real data from it is provided. A phenomenological model is finally provided, attempting to accomodate experimental evidence.

The characteristics of the phase- and wall-locked mode found in a large-sized reversed-field pinch (RFP) machine TPE-RX [Y. Yagi et al. Plasma Phys. Controlled Fusion 41, 255 (1999)] are described in detail. The toroidally-localized radial magnetic field starts to grow after the setup of the RFP configuration in a current rising phase, reaching up to 2% of the poloidal magnetic field at the plasma surface, and stays at the same toroidal location throughout the discharge. The mode frequently locks to the thick shell gap position with a 20%–30% probability. The plasma–wall interaction is enhanced at the locked position where the thermal wall load is peaked by a factor of about 3 on average. The locked mode disappears in some experimental conditions. The probability for the locked mode to appear depends on the experimental conditions, especially on the filling pressure of the fueling gas and on the rise time of the plasma current. Possible causes of the locked mode are discussed from the braking effect of the eddy current as well as from the halo current in the vacuum vessel.