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Background:Our study is an analysis of the histological and radiological changes in degenerated lumbar intervertebral discs, after transplantation of fibroblasts in rabbits. With that study we aimed to show the viability of the fibroblasts injected to the degenerated discs, and observe their potential for further studies.Method:The apoptosis of the cell is one of the factors at the disc degeneration process. Fibroblasts may act as mesenchymal stem cells at the tissue to which they are injected and they may replace the apoptotic cells. The nucleus pulposus of the discs from eight rabbits were aspirated under scopic guidance to induce disc degeneration.Results:One month later, cultured fibroblasts, which had been taken from the skin, were injected into the disc. The viability and the potential of the injected cells for reproduction were studied histologically and radiologically. Cellular formations and organizations indicating to the histological recovery were observed at the discs to which fibroblasts were transplanted. The histological findings of the discs to which no fibroblasts were transplanted, did not show any histological recovery. Radiologically, no finding of the improvement was found in both groups. The fibroblasts injected to the degenerated discs are viable.Conclusion:The findings of improvement, observed in this study, suggest that fibroblast transplantation could be an effective method of therapy for the prevention or for the retardation of the degenerative disease of the discs.

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The purpose of the present study is to examine and compare the trachea and larynx caudalis of budgerigars and canaries in a macroanatomic manner. 18 canaries and 29 budgerigars that were collected as dead from the clinics of the surrounding area were used in this study. The number of cartilago trachea was 46-47 in canaries; and 53-61 in budgerigars. Crossman's Triple Staining Method was used for histological examinations. 0.1% methylene blue solution was used to examine in a stereo microscope. Tracheobronchial-type syrinx was observed in both species. In canaries last 4-5 trachea rings were joined together to form the tympanum. It was observed that in all species the trachea rings were full. The ligamentum annulare and musculus trachealis were not observed in both species. While pessulus and tympanum were observed in canaries, they were not detected in budgerigars. Musculi syringeales was detected in budgerigars in an extremely developed structure. Cartilagines bronchosyringeales formed the last part of the syrinx; and it consisted 8-9 cartilages in canaries and 6-7 cartilages in budgerigars.